AI Article Synopsis
- A new method was created to obtain ovoid resting forms of Mycobacterium smegmatis, which look different from the typical rod-like cells.
- These ovoid forms show significantly lower metabolic activity, are more resistant to heat and antibiotics, and can be stored for over two months while still able to form colonies.
- The ovoid resting forms can be useful in testing the effectiveness of new treatments for latent tuberculosis and studying the genes involved in their dormant state.
Article Abstract
The new model of obtaining of ovoid resting forms Mycobacterium smegmatis, which are morphologically different from vegetative (rod-like) cells, was developed. Ovoid forms were characterized by a drastically decreased level of metabolic activity, an increased stability to heat processing and antibiotics action, and also by prolonged (more than 2 months) storage time preserving colony-forming ability. Obtained resting forms of mycobacteria may be used in test-systems for checking efficiency of new medical agents against latent forms of tuberculosis and determination of role of these of those genes in entering rest state.
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