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Calycosin suppresses expression of pro-inflammatory cytokines via the activation of p62/Nrf2-linked heme oxygenase 1 in rheumatoid arthritis synovial fibroblasts.
Pharmacol Res
November 2016
State Key Laboratory of Quality Research in Chinese Medicine/Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Macau, China. Electronic address:
The activation of synovial fibroblasts (SFs) and the subsequent production and expression of pro-inflammatory cytokines play a crucial role in the pathogenesis and progression of rheumatoid arthritis (RA). In the current study, rheumatoid arthritis synovial fibroblasts (RASFs) isolated from the joint of the patients were used to evaluate the suppressive effects of calycosin (CAL), a compound derived from the Chinese medicinal herb Radix Astragali, on the expression of pro-inflammatory cytokines in RASFs. The results demonstrated that increased mRNA expression levels of interleukin-1β (IL-1β), interleukin-6 (IL-6), interleukin-8 (IL-8), interleukin-25 (IL-25), interleukin-33(IL-33) were significantly inhibited by CAL.
View Article and Find Full Text PDFInhibition of pro-inflammatory mediators: role of Bacopa monniera (L.) Wettst.
Inflammopharmacology
October 2011
Department of Biochemistry, University of Kerala, Kariavattom Campus, Thiruvanthapuram, 695 581, Kerala, India.
Bacopa monniera (L.) Wettst is a renowned plant in the Ayurvedic system of medicine. The present study seeks to identify the anti-inflammatory activity of two fractions from the methanolic extract of Bacopa, viz.
View Article and Find Full Text PDFBacopa monniera (L.) wettst inhibits type II collagen-induced arthritis in rats.
Phytother Res
September 2010
Department of Biochemistry, University of Kerala, Kariavattom Campus, Thiruvanthapuram, Kerala, India 695 581.
Bacopa monniera (L.) Wettst is an Ayurvedic herb with antirheumatic potential. This study investigated the therapeutic efficacy of Bacopa monniera in treating rheumatoid arthritis using a type II collagen-induced arthritis rat model.
View Article and Find Full Text PDFAntiarthritic profile of BF-389--a novel anti-inflammatory agent with low ulcerogenic liability.
Agents Actions
September 1992
Biofor Limited, Waverly, PA.
BF-389, dihydro-4-(3,5-di-tert-butyl-4-hydroxybenzylidene)-2-methyl-2H-1,2- oxazin-3(4H)-one, is a potent, orally active, antiarthritic and analgesic agent with low ulcerogenic potential. A comparison of the activity profiles of BF-389 and naproxen showed similarities in: (1) suppression of developing and chronic adjuvant arthritis (AA); (2) maximal inhibitory response, as shown by the E(max) values in the developing and established AA models; (3) inhibition of bone degenerative changes associated with chronic adjuvant arthritis; and (4) analgesic activity in the acetic acid and phenylquinone writhing assays. Though BF-389 has been shown to be a potent inhibitor of cyclooxygenase, IC50 = 0.
View Article and Find Full Text PDFZK 90 695: a new antiarthritic drug with tissue targeting properties.
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January 1991
Research Laboratories, Schering AG, Berlin.
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