A labdane diterpene dialdehyde was first time isolated from the chloroform extract of rhizomes of Curcuma amada. This compound exhibited antitubercular activity (MIC=500 microg/mL) against Mycobacterium tuberculosis H(37)Rv strain in BACTEC-460 assay. Two of its semisynthetic analogues also exhibited antitubercular activity at 250-500 microg/mL. It is the first report on isolation and antimycobacterial activity of this dialdehyde from C. amada.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.ejmech.2010.06.006 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Bioinspired copper oxide nanocomposites: harnessing plant extracts for enhanced photocatalytic performance.
Environ Sci Pollut Res Int
August 2024
Department of Chemistry, Gobi Arts & Science College, Gobichettipalayam, 638453, Erode, Tamil Nadu, India.
This study focuses on developing copper oxide-based nanocomposites using plant extracts for photocatalytic applications. Curcuma amada leaf and Alysicarpus vaginalis leaf extracts were utilized alongside recycled copper precursors to synthesize photocatalysts via a green synthesis approach. Structural characterization through X-ray diffraction confirmed the formation of monoclinic CuO with reduced crystallite sizes due to plant extract incorporation.
View Article and Find Full Text PDFFacile Green Synthesis of Iron Oxide Nanoparticles and Their Impact on Cytotoxicity, Antioxidative Properties and Bactericidal Activity.
Iran Biomed J
March 2024
Department of Life Sciences, Biotechnology Division, School of Science, GSFC University, Vadodara-391750, Gujarat, India.
Background: Bioreductive processes are quite potent, effective and affordable for the synthesis of green nanoparticles (NPs), as compared to the physical and chemical methods. The present study aimed to evaluate the bactericidal, antioxidative and anticancer activity of turmeric rhizome-iron oxide nanoparticles (FeONPs) derived from the turmeric rhizome (Curcuma amada) using ferric chloride as a precursor.
Methods: With focusing on the manufacture of FeONPs via green approach, we characterized the NPs using FTIR, FT-Vis, DLS, and UV-Vis spectroscopy.
Linker-Based Pharmacophoric Design and Semisynthesis of Labdane Conjugates Active against Multi-Faceted Inflammatory Targets.
J Agric Food Chem
March 2024
Chemical Sciences and Technology Division, CSIR-National Institute for Interdisciplinary Science and Technology (CSIR-NIIST), Thiruvananthapuram 695 019, Kerala, India.
Prolonged inflammation leads to the genesis of various inflammatory diseases such as atherosclerosis, cancer, inflammatory bowel disease, Alzheimer's, etc. The uncontrolled inflammatory response is characterized by the excessive release of pro-inflammatory mediators such as nitric oxide (NO), tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), interleukin-1alpha (IL-1α), and inflammatory enzymes such as cyclooxygenase-2 (COX-2). Hence, the downregulation of these inflammatory mediators is an active therapy to control aberrant inflammation and tissue damage.
View Article and Find Full Text PDFanti-hyperglycemic effect of herbal extracts (L) and (R) on streptozotocin-induced diabetic rats and its associated histopathological studies.
Heliyon
January 2024
Department of Computational Biology, Saveetha School of Engineering, Saveetha Institute of Medical and Technical Sciences (SIMATS), Chennai, India.
Article Synopsis
- Diabetes is a major health issue linked to high blood sugar, obesity, and organ failure, making it important to find effective treatments, especially from natural sources with minimal side effects.
- A study tested a combined herbal aqueous extract of two plants on diabetic rats for 37 days, measuring blood glucose levels and other health indicators.
- The results showed that the herbal extracts significantly reduced blood glucose, increased insulin and glycogen levels, and improved overall health compared to the standard drug Glibenclamide, suggesting their potential as antidiabetic agents in Ayurvedic medicine.
Antimicrobial activity of Curcuma amada extract on Streptococcus mutans-An study.
J Oral Maxillofac Pathol
July 2023
Department of Oral Pathology and Microbiology, Vydehi Institute of Dental Sciences and Research Centre, Bengaluru, Karnataka, India.
Context: Dental caries is prevalent in spite of widespread use of mechanical and chemical plaque control methods. Streptococcus mutans is said to have a strong background in initiation of dental caries. Hence, exceptional methods are required which would be effective against dental caries.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!