Chang Gung Med J
Nephrology Division, Department of Internal Medicine, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung, Taiwan.
Published: October 2010
Background: The number of elderly people with end-stage renal disease has grown in developed countries and medical teams now face the choice of dialysis therapy in elderly patients. In the present study, we retrospectively analyzed two peritoneal dialysis (PD) patients, of different ages, who were treated at the same unit by the same PD team of doctors and nurses. Our purpose was to study peritoneal membrane changes in elderly and younger PD patients.
Methods: 108 patients above 60 years of age or younger at the start of dialysis, were separated into two cohorts. Diabetic patients were excluded. Peritoneal equilibration test (PET) results taken over 4 continuous years were compared between the two groups.
Results: No significant differences were seen between the two groups in peritoneal transport (D/P Cr, D/D0 glucose) during the 4-year observation. Total Kt/V and renal creatinine clearance (Ccr) values in the 4-year period were not significantly different between the two groups. Renal Ccr values showed a longitudinal decline in the two groups but the values of total Kt/V revealed a consistency over the 4-year period.
Conclusion: Elderly PD patients demonstrated a similar peritoneal permeability to younger PD patients based on a 4-year PET.
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Einstein (Sao Paulo)
December 2024
Internal Medicine Department, Faculdade de Medicina de Botucatu, Universidade Estadual Paulista, Botucatu, SP, Brazil.
Objective: The efficacy of icodextrin versus glucose patients undergoing peritoneal dialysis remains unclear. The study was designed to compare the effects of once-daily long-dwell icodextrin versus glucose on markers of hypervolemia and survival among patients with kidney failure undergoing an unplanned initiation of automated peritoneal dialysis.
Methods: This was a randomized, non-blinded, and prospective controlled study.
Ther Apher Dial
November 2024
Department of Pharmacy, Nanjing Drum Tower Hospital, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, China.
Introduction: The connection between peritoneal function and gut microbiota in peritoneal fibrosis (PF) patients remains uncertain.
Methods: Peritoneal equilibration test (PET) was employed to evaluate peritoneal function in patients with peritoneal fibrosis (PF). 16S rRNA sequencing was used to analyze the gut flora in incident peritoneal dialysis (PD) and PF groups, identifying differential microbial communities.
Clin Exp Nephrol
October 2024
Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.
Background: Encapsulated peritoneal sclerosis (EPS) is a serious complication in patients undergoing peritoneal dialysis (PD). Neutral-pH dialysate is associated with less peritoneal damage and a lower incidence of EPS than conventional PD solution. However, monitoring for peritoneal damage and predicting EPS remain important during PD therapy.
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September 2024
Department of Nephrology and Rheumatology, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan.
Introduction: Peritoneal equilibration test (PET) has been used to monitor peritoneal function. A more convenient marker would be useful in clinical situations including home medical care. Autotaxin is known to leak into the interstitium as vascular permeability increases during the progression of tissue fibrosis.
View Article and Find Full Text PDFClin Kidney J
September 2024
Department of Nephrology, Peking University People's Hospital, Beijing, China.
Background: The peritoneal solute transport rate (PSTR) tends to increase over time in some patients undergoing peritoneal dialysis (PD), potentially leading to ultrafiltration (UF) failure. Previous case reports have shown a significant decrease in PSTR and subsequent recovery of UF after discontinuing PD for a while. Therefore, we conducted a randomized controlled crossover study to evaluate the impact of short-term peritoneal rest on PSTR.
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