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Absence of platelet overactivation and thrombosis formation among patients with coronary atherosclerosis disease after vaccination against SARS-CoV-2.
Heliyon
October 2024
Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases, Shanghai, National Clinical Research Center for Interventional Medicine, China.
Article Synopsis
- The study investigated concerns about whether COVID-19 vaccines are linked to thrombosis (blood clots) in patients with coronary atherosclerosis and in atherosclerotic mice.
- Researchers found no significant difference in thrombus formation or platelet activation between vaccinated and unvaccinated groups of both mice and CAD patients after vaccination.
- The results suggest that inactivated SARS-CoV-2 vaccines do not increase the risk of thrombosis or activate platelets any more than saline treatments, indicating they might be safer compared to adenovirus-based vaccines.
Ruthenium Antivenom Inhibits the Defibrinogenating Activity of Venom in Rabbits.
Int J Mol Sci
June 2024
Department of Anesthesiology, The University of Arizona College of Medicine, Tucson, AZ 85724, USA.
Eastern Diamondback Rattlesnake () envenomation is a medical emergency encountered in the Southeastern United States. The venom contains a snake venom thrombin-like enzyme (SVTLE) that is defibrinogenating, causing coagulopathy without effects on platelets in humans. This investigation utilized thrombelastographic methods to document this coagulopathy kinetically on the molecular level in a rabbit model of envenomation via the analyses of whole blood samples without and with platelet inhibition.
View Article and Find Full Text PDFCombined Administration of Fibrinogen and Factor XIII Concentrate Does Not Improve Dilutional Coagulopathy Superiorly Than Sole Fibrinogen Therapy: Results of an In-Vitro Thrombelastographic Study.
J Clin Med
May 2021
Department of Anesthesiology, Operative Intensive Care Medicine and Pain Therapy, University Hospital of Giessen, 35392 Giessen, Germany.
The early administration of fibrinogen has gained wide acceptance for the treatment of major hemorrhage, whereas the substitution of coagulation factor XIII (FXIII) is only supported by a low level of evidence. This study aimed to answer the question of whether a combined therapy of fibrinogen/FXIII substitution performs superiorly to sole fibrinogen administration in the treatment of dilutional coagulopathy. An in-vitro model of massive transfusion was used to compare the effect of combined fibrinogen/FXIII administration to that of sole fibrinogen therapy for the treatment of dilutional coagulopathy.
View Article and Find Full Text PDFValue of thromboelastography combined with anticoagulant detection in patients over 60 years of age with cardiovascular or cerebrovascular disease.
Ann Palliat Med
May 2021
Department of Clinical Laboratory, the Second Hospital of Jilin University, Changchun, China.
Background: Cardiovascular disease (CVD) and cerebrovascular disease (CBVD) are common diseases in middle-aged and elderly people with high morbidity, mortality and disability rates. Individualized assessment and treatment are helpful to improve the quality of life and prognosis of patients. Thrombelastography (TEG) is a method to evaluate the coagulation function of patient with whole blood.
View Article and Find Full Text PDFBackground Hypergravity may promote human hemostasis thereby increasing thrombotic risk. Future touristic suborbital spaceflight will expose older individuals with chronic medical conditions, who are at much higher thromboembolic risk compared with professional astronauts, to hypergravity. Therefore, we tested the impact of hypergravity on hemostasis in healthy volunteers undergoing centrifugation.
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