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Organizational Initiatives for the Recruitment, Retention and Advancement of Black Nurses: A Rapid Review.
Nurs Leadersh (Tor Ont)
June 2025
Adjunct Professor School of Nursing, Faculty of Health Department of Community Health and Epidemiology, Faculty of Medicine Faculty of Graduate Studies Dalhousie University Halifax, NS.
Introduction: Black nurses are under-represented in the Canadian nursing workforce. A legacy of discrimination and systemic barriers reinforce the under-representation of Black nurses in the nursing workforce throughout the health system.
Objective: The objective of this study was to identify and describe organizational initiatives for the recruitment, retention and advancement of Black nurses in the healthcare system.
Real-World Impact of Olaparib Exposure in Advanced Pancreatic Cancer Patients Harboring Germline BRCA1-2 Pathogenic Variants.
Cancer Med
February 2025
Department of Medical Oncology, IRCCS Ospedale San Raffaele, Milan, Italy.
Introduction: Pancreatic cancer arising in the context of BRCA predisposition may benefit from poly(ADP-ribose) polymerase inhibitors. We analyzed real-world data on the impact of olaparib on survival in metastatic pancreatic cancer patients harboring germline BRCA mutations in Italy, where olaparib is not reimbursed for this indication.
Methods: Clinico/pathological data of pancreatic cancer patients with documented BRCA1-2 germline pathogenic variants who had received first-line chemotherapy for metastatic disease were collected from 23 Italian oncology departments and the impact of olaparib exposure on overall survival (OS) was analyzed.
A Compendium of Magnetic Nanoparticle Essentials: A Comprehensive Guide for Beginners and Experts.
Pharmaceutics
January 2025
Physics Department and i3N, University of Aveiro, Campus de Santiago, 3810-193 Aveiro, Portugal.
Magnetic nanoparticles (MNPs) are advanced materials that combine the unique properties of magnetic materials and nanoscale dimensions, enabling a wide range of applications in biomedicine, environmental science, and information technology. This review provides a comprehensive yet accessible introduction to the fundamental principles, characterization techniques, and diverse applications of MNPs, with a focus on their nanoscale magnetic properties, such as superparamagnetism, single-domain behavior, and surface effects. It also delves into their classification and the critical role of parameters like magnetic anisotropy and blocking temperature.
View Article and Find Full Text PDFTargeting Brain Drug Delivery with Macromolecules Through Receptor-Mediated Transcytosis.
Pharmaceutics
January 2025
Key Laboratory of Molecular Biophysics, Institute of Biophysics, School of Health Sciences & Biomedical Engineering, Hebei University of Technology, Tianjin 300401, China.
Brain diseases pose significant treatment challenges due to the restrictive nature of the blood-brain barrier (BBB). Recent advances in targeting macromolecules offer promising avenues for overcoming these obstacles through receptor-mediated transcytosis (RMT). We summarize the current progress in targeting brain drug delivery with macromolecules for brain diseases.
View Article and Find Full Text PDFRelationship Between the Gut Microbiome, Tryptophan-Derived Metabolites, and Osteoarthritis-Related Pain: A Systematic Review with Meta-Analysis.
Nutrients
January 2025
Grupo de Investigación en Calidad de Vida y Salud, Departamento de Ciencias de la Salud, Universidad Europea de Valencia, 03016 Alicante, Spain.
Introduction: Osteoarthritis (OA) is the most prevalent form of arthritis and affects over 528 million people worldwide. Degenerative joint disease involves cartilage degradation, subchondral bone remodeling, and synovial inflammation, leading to chronic pain, stiffness, and impaired joint function. Initially regarded as a "wear and tear" condition associated with aging and mechanical stress, OA is now recognized as a multifaceted disease influenced by systemic factors such as metabolic syndrome, obesity, and chronic low-grade inflammation.
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