Limited study of persistent organochlorine pesticides (OCPs) and endometriosis has been conducted. One hundred women aged 18-40 years who were undergoing laparoscopy provided 20 cm(3) of blood for toxicologic analysis and surgeons completed operative reports regarding the presence of endometriosis. Gas chromatography with electron capture was used to quantify (ng/g serum) six OCPs. Logistic regression was utilized to estimate the adjusted odds ratios (aOR) and 95% confidence intervals (CI) for individual pesticides and groups based on chemical structure adjusting for current cigarette smoking and lipids. The highest tertile of aromatic fungicide was associated with a fivefold risk of endometriosis (aOR=5.3; 95% CI, 1.2-23.6) compared to the lowest tertile. Similar results were found for t-nonachlor and HCB. These are the first such findings in a laproscopic cohort that suggest an association between OCP exposure and endometriosis. More prospective studies are necessary to ensure temporal ordering and confirm these findings.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4133942 | PMC |
| http://dx.doi.org/10.1016/j.reprotox.2010.05.011 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Residual, Enrichment and Health Risk Assessment of Hexachlorocyclohexane and Dichlorodiphenyltrichloroethane in Muscle of Cultured Common Carp.
Foods
January 2025
Heilongjiang River Fisheries Research Institute, Chinese Academy of Fishery Sciences, Harbin 150070, China.
Common carp () is extensively cultured and widely consumed in Heilongjiang Province, China. Due to the proximity of freshwater ponds to agricultural cultivated areas, these aquatic systems are inevitably influenced by the historical application of organochlorine pesticides (OCPs), due to their prolonged half-life and resistance to degradation. Gas chromatography-tandem mass spectrometry (GC-MS/MS) was utilized to quantify the levels of hexachlorocyclohexane (HCHs) and dichlorodiphenyltrichloroethane (DDTs) in the muscle tissue of cultured common carp.
View Article and Find Full Text PDFAlterations in murine macrophage reactivity and bactericidal efficacy following exposure to an environmentally relevant mixture of organochlorine pesticide compounds.
Food Chem Toxicol
January 2025
Mississippi State University College of Veterinary Medicine, Department of Comparative Biomedical Sciences, Mississippi State University, MS, USA.
While there are a number of factors which may promote chronic inflammation, a major factor is pro-inflammatory activation of resident and infiltrating macrophages. Recently, exposures to persistent organic pollutants including organochlorine (OC) pesticides have been implicated in dysregulation of macrophage function. However, the majority of these studies examined single compound effects and not mixture-based effects.
View Article and Find Full Text PDFTissue bioaccumulation and distribution of organic contaminants in Brazilian guitarfish Pseudobatos horkelii reveal a concerning impact of contraceptive hormones and fecal sterols.
Mar Pollut Bull
January 2025
Instituto de Ciências Biológicas, Universidade Federal do Rio Grande - FURG, Rio Grande, RS, Brazil. Electronic address:
The critically endangered Brazilian guitarfish faces significant threats from environmental contamination. Assessing the impacts of such stressor is paramount from a conservational perspective. This study investigated the concentrations, distribution and accumulation patterns of organic contaminants in pregnant Brazilian guitarfish Pseudobatos horkelii.
View Article and Find Full Text PDFDistribution and bioconcentration of semivolatile organic compounds (SVOCs) in soils and vascular plant Colobanthus quitensis from Sub-Antarctic and Antarctic regions.
Sci Total Environ
January 2025
Centro de Genómica, Ecología y Medio Ambiente (GEMA), Universidad Mayor, Campus Huechuraba, Santiago, Chile; Institute of Environment, Florida International University, University Park, Miami, FL 33199, USA; Data Observatory Foundation, Santiago, Chile. Electronic address:
Semi-volatile organic compounds (SVOCs) are widely distributed across the globe, including polar regions. This study investigates the distribution and bioconcentration of organochlorine pesticides (OCPs), polychlorinated biphenyls (PCBs), and polycyclic aromatic hydrocarbons (PAHs) in soils and Colobanthus quitensis, while also estimating potential emission sources. Results indicated high concentrations of PAHs in soils and plants from the Sub-Antarctic region, while OCPs and PCBs were more prevalent in the Antarctic region, with higher contaminant concentrations found in soils than in plant tissues.
View Article and Find Full Text PDFNano-interface enhanced electrochemical sensing of hazardous organochlorine pesticides and prospects with ZnO based nanomaterials.
Talanta
January 2025
Department of Electronics and Communication Engineering, Tezpur University, Tezpur, 784028, India. Electronic address:
Detection and analysis of organochlorine pesticides (OCP) residue is getting significant research importance because of their extensive use despite their hazardous effects on the health of people and the ecosystem. Despite the implementation of regulations and bans to safeguard human health and the environment, reports frequently reveal the continued use of these harmful chemicals in quantities exceeding the recommended limits set by regulatory boards. Data on the use of OCP from India, the most populous country, and African countries is not very encouraging.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!