Objectives: Determining post-tonsillectomy haemorrhage (PTH) risk factors is crucial for preventing it. The aim of the study was to analyse results of coagulation tests and preoperative family and medical history of coagulation disorders in order to establish if they have predictive value for PTH.
Methods: In 222 patients aged 15-60 years, values of APTT (Activated Partial Thromboplastin Time), prothrombin/INR ratio and platelet count as well as medical history were analysed and 15 episodes of secondary PTH occurred. This includes 3 of 9 (33.3%) patients with medical history of proneness to bruises after minor trauma and in all (4) patients who declared both relevant medical history of proneness to bruise formation after minor trauma and proneness to prolonged bleeding after injury.
Results: Five individuals had elevated APTT values and proneness to bruise formation after minor trauma, and other six patients had elevated APTT values, relevant history of frequent epistaxis and family coagulation disorders. In none of these patients PTH occurred. There was one episode of primary and no secondary PTH in 15 patients with values of APTT elevated < or =10% of the normal value. No PTH occurred in 6 individuals with APTT elevated by >10% of the normal value. Haemorrhage rate correlated with APTT results, proneness to bruise formation and to bleeding after injuries. Values of specificity of recurrent epistaxis, history of bruises after minor trauma and prolonged bleeding after injury were significant.
Conclusions: In healthy adults, coagulation tests results are irrelevant for the course of tonsillectomy and postoperative bleeding event. Personal medical history is important in predicting PTH.
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http://dx.doi.org/10.1016/j.otorri.2010.01.017 | DOI Listing |
Curr Drug Saf
January 2025
National Center Chalbi Belkahia of Pharmacovigilance, Department of Collection and Analysis of Adverse Effects, Tunis, Tunisia, University of Tunis El Manar, Faculty of Medicine, Research unit: UR17ES12, Tunis, Tunisia.
Background: Trimethoprim-Sulfamethoxazole (TMP-SMX) is a commonly used antibiotic for the treatment of several infections, such as urinary tract infections, respiratory infections, and in certain cases, septic arthritis. Rhabdomyolysis (RM) is very rare and less than 20 cases have been reported, so far, in the literature, in particular in immunocompromised patients. Here, we report a case of TMP-SMX-induced RM in an immunocompetent patient, adding to the limited data on this association.
View Article and Find Full Text PDFInfect Disord Drug Targets
January 2025
HCA Healthcare Las Palmas/Del Sol Internal Medicine Program.
Background: Streptococcal Toxic Shock Syndrome (STSS) is a life-threatening condition caused by bacterial toxins. The STSS triad encompasses high fever, hypotensive shock, and a "sunburn-like" rash with desquamation. STSS, like Toxic Shock Syndrome (TSS), is a rare complication of streptococcal infec-tions caused by Group A Streptococcus (GAS), Streptococcal pyogenes (S.
View Article and Find Full Text PDFPLoS Biol
January 2025
Department of Biology, University of Washington, Seattle, Washington, United States of America.
Body size declines are a common response to warming via both plasticity and evolution, but variable size responses have been observed for terrestrial ectotherms. We investigate how temperature-dependent development and growth rates in ectothermic organisms induce variation in size responses. Leveraging long-term data for six montane grasshopper species spanning 1,768-3 901 m, we detect size shifts since ~1960 that depend on elevation and species' seasonal timing.
View Article and Find Full Text PDFCureus
December 2024
Internal Medicine Department, Hamad Medical Corporation, Doha, QAT.
Hemophagocytic lymphohistiocytosis (HLH) is a rare, life-threatening syndrome of excessive immune activation, leading to severe inflammation and organ damage. While more common in infants, HLH can occur at any age and is often triggered by infections such as Epstein-Barr virus (EBV). In this case, a 38-year-old man presented with a three-week history of fevers, night sweats, poor appetite, and severe anemia.
View Article and Find Full Text PDFTransplant Direct
February 2025
Department of Medicine, UMass Chan Medical School, Worcester, MA.
Background: As the burden of chronic liver disease and the demand for liver transplants (LT) grows, understanding the interplay between access to care and patient outcomes is increasingly important. In this study, we explored patient characteristics and transplant outcomes in patients undergoing LT evaluations, with a focus on identifying risk factors for expedited LT evaluation.
Methods: This single-center retrospective cohort study included patients who underwent LT evaluation for deceased donor LT between October 2017 and July 2021.
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