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Kounis syndrome following COVID-19 vaccination: Clinical manifestations, mechanisms and management.
Hum Vaccin Immunother
December 2024
Department of Pediatrics, The Third Xiangya Hospital, Central South University, Changsha, Hunan Province, China.
Article Synopsis
- Kounis syndrome is an acute coronary condition triggered by allergic reactions, resulting in heart damage and, in some cases, anaphylactic shock.
- This syndrome can occur as a rare side effect of COVID-19 vaccinations, highlighting the need for further case studies to improve understanding and treatments.
- Analysis of data from 15 patients revealed that the first vaccine dose is more likely to cause Kounis syndrome, emphasizing the importance of prompt diagnosis and monitoring for cardiac symptoms after vaccination.
Subacute Stent Thrombosis Related to Kounis Syndrome During Anaphylaxis Induced by Ultrasound Contrast Agent Infusion.
JACC Case Rep
November 2024
Interventional Cardiology, Careggi University Hospital, Florence, Italy.
Article Synopsis
- A 44-year-old man experienced a severe allergic reaction after receiving SonoVue during a heart test, leading to chest pain and a heart attack caused by stent thrombosis and coronary vasospasm.
- Treatment involved mechanical thrombectomy, stent replacement, and careful management to avoid worsening the patient's condition, ultimately resulting in his recovery and discharge with normal heart function.
Drug-induced Kounis Syndrome: A Retrospective Pharmacovigilance Study from the FAERS and JADER Databases.
J Investig Allergol Clin Immunol
November 2024
Department of Cardiology, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, China.
ATAK Complex Induced by Ranitidine: A Comprehensive Concept for Cardiac Involvement in Allergic Reactions.
J Investig Allergol Clin Immunol
November 2024
Department of Allergy, Instituto de Investigación Sanitaria Princesa (IIS-Princesa), Hospital Universitario de La Princesa, Madrid, Spain.
Kounis syndrome (KS) was first described in 1991 by Kounis and Zavras and is also known as allergic angina syndrome or allergy myocardial infarction. It is a rare, and frequently undiagnosed syndrome that is characterized by an anaphylactic reaction. Allergens cause massive degranulation of mast cells leading to coronary spasm, microvascular angina, and/or endothelial dysfunction with myocardial infarction.
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