The search for a coherent account of one's life and one's origin may become a particularly powerful organizer of fantasy and memory, affect and conflict, self and object representation in adopted children. Yet relinquishment, unacknowledged affects, and inaccessible history create a rupture in the fabric of that narrative. Clinical material is presented to illustrate the impact such disruptions may have on the personal narrative and the developing selfhood of the child, with a particular focus on the impact of inhibited mourning. The evolving play showed that grieving facilitated representation of losses and discontinuities and made possible a more integrated representation of the self.
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Sci Rep
November 2024
PRINCE Laboratory Research, ISITcom, Hammam Sousse, University of Sousse, Sousse, Tunisia.
Having access to potable water is a fundamental right to well-being. Despite this, 3.4 million people die from diseases caused by water each year, and 1.
View Article and Find Full Text PDFCurr Oncol
November 2024
Biomedical Department, Centre Scientifique de Monaco, 98000 Monaco, Monaco.
Medulloblastoma, a malignant pediatric brain tumor, has a poor prognosis upon relapse, highlighting a critical clinical need. Our previous research linked medulloblastoma cell radioresistance to integrin-αvβ3 expression. β3-depleted (β3_KO) medulloblastoma cells exhibit lipid hydroxyperoxide accumulation after radiotherapy, indicating ferroptosis, a regulated cell death induced by ROS and inhibited by antioxidants such as cysteine, glutathione (GSH), and glutathione peroxidase 4 (GPx4).
View Article and Find Full Text PDFSci Rep
October 2024
Princess Srisavangavadhana College of Medicine, Chulabhorn Royal Academy, Bangkok, 10210, Thailand.
J Palliat Care
January 2025
Institute of Neurological Sciences, Queen Elizabeth University Hospital, Glasgow, UK.
Motor neuron disease is a rapidly progressing neurological condition. People with life-limiting conditions generally prefer to die at home and avoid hospital admissions, with Specialist Palliative Care Team involvement often pivotal. Our aim was to investigate the role of advance care planning, Specialist Palliative Care Team input and other relevant variables on place of death and unscheduled hospital admissions in a Scottish population of people with motor neuron disease.
View Article and Find Full Text PDFPediatr Blood Cancer
December 2024
Department of Children and Adolescents Oncology, Gustave Roussy Cancer, Paris-Saclay University, Villejuif, France.
Background: Constitutional mismatch repair deficiency syndrome (CMMRD) is a rare childhood cancer predisposition syndrome associated with a broad spectrum of malignancies, including non-Hodgkin lymphomas (NHL). Most patients die due to cancer before the age of 20 years. Limited data exist on CMMRD-associated lymphomas and their outcome.
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