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Advances in the Treatment of Congenital Infiltrating Lipomatosis of the Face: The Role of PIK3CA Mutations and Microvascular Reconstruction.
J Craniofac Surg
October 2024
Department of Oral Maxillofacial Surgery, Walter Reed National Military Medical Center.
Congenital infiltrating lipomatosis of the face is a rare aggressive-benign disorder characterized by progressive hemifacial overgrowth and complex, often asymmetrical, facial differences. Recently linked with the PIK3CA-Related Overgrowth Spectrum, it arises from mosaic mutations in the PIK3CA gene. Treatment, largely supportive and tailored to individual clinical presentations, requires a multidisciplinary approach.
View Article and Find Full Text PDFPATHOGENESIS OF RADIATION COMPLICATIONS IN NORMAL TISSUES SURROUNDING AN IRRADIATED TUMOUR (review).
Probl Radiac Med Radiobiol
December 2024
R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology, National Academy of Sciences of Ukraine, 45 Vasylkivska Str., Kyiv, 03022, Ukraine.
The introduction of new radiation technologies in modern radiotherapy of cancer patients is still in some cases associated with the risk of developing early and distant complications in healthy tissues surrounding the tumour. The causes of their occurrence, pathogenesis and radiobiological characteristics are reviewed and briefly described. The rate of the manifestation of complications depends on the radiosensitivity of tissues and is determined by the amount of absorbed dose of ionizing radiation.
View Article and Find Full Text PDFThe influence of microbiota on the efficacy and toxicity of immunotherapy in cancer treatment.
Mol Biol Rep
December 2024
Cancer Research Center, Semnan University of Medical Sciences, Semnan, Iran.
Immunotherapy, which uses the body's immune system to fight cancer cells, has gained attention recently as a breakthrough in cancer treatment. Although significant progress has been made, obstacles still exist since cancers are skilled at avoiding immune monitoring. The gut microbiota is being looked at more and more in modern research as a critical component in improving the results of immunotherapy.
View Article and Find Full Text PDFAdvancements of aquaporin 1 in ultrafiltration failure secondary to peritoneal dialysis.
Pediatr Nephrol
December 2024
Department of Nephrology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, China.
For patients undergoing long-term peritoneal dialysis (PD), exposure to biologically incompatible PD solutions and the consequent peritoneal structure change can lead to progressive angiogenesis and fibrosis, and ultimately result in ultrafiltration failure (UFF). Peritoneal transport studies in aquaporin 1 (AQP1) knockout mice indicate that water transport across the peritoneum is mediated by AQP1, which accounts for up to 50% of ultrafiltration. Another recent study on a large cohort of PD patients with kidney failure further substantiated the impact of AQP1 genotype variation on water channel expression in the peritoneal membrane, influencing water transport, ultrafiltration, and patient prognosis.
View Article and Find Full Text PDFAn in silico framework to visualize how cancer-associated mutations influence structural plasticity of the chemokine receptor CCR3.
Protein Sci
January 2025
Department of Chemistry and Biochemistry, Texas Tech University, Lubbock, Texas, USA.
G protein Coupled Receptors (GPCRs) are the largest family of cell surface receptors in humans. Somatic mutations in GPCRs are implicated in cancer progression and metastasis, but mechanisms are poorly understood. Emerging evidence implicates perturbation of intra-receptor activation pathway motifs whereby extracellular signals are transmitted intracellularly.
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