External referencing (ER) imposes a price cap for pharmaceuticals, based on prices of identical or comparable products in foreign countries. Suppose a foreign country (F) negotiates prices with a pharmaceutical firm, whereas a home country (H) can either negotiate prices independently or implement ER, based on the foreign price. We show that country H prefers ER if copayments in H are relatively high. This preference is reinforced when H's population is small. Irrespective of relative country sizes, ER by country H harms country F. Our model is inspired by the wide European experience with this cost-containment policy. Namely, in Europe, drug authorization and price negotiations are carried out by separate agencies. We confirm our main results in two extensions. The first one allows for therapeutic competition between drugs. In the second one, drug authorization and price negotiation take place in a single agency.
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http://dx.doi.org/10.1002/hec.1630 | DOI Listing |
NPJ Digit Med
January 2025
Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Cardiac wall motion abnormalities (WMA) are strong predictors of mortality, but current screening methods using Q waves from electrocardiograms (ECGs) have limited accuracy and vary across racial and ethnic groups. This study aimed to identify novel ECG features using deep learning to enhance WMA detection, referencing echocardiography as the gold standard. We collected ECG and echocardiogram data from 35,210 patients in California and labeled WMA using unstructured language parsing of echocardiographic reports.
View Article and Find Full Text PDFJ Eat Disord
December 2024
School of Social Sciences, Arts Design and Architecture, University of New South Wales, Sydney, Australia.
Purpose: To examine autonomy within treatment and recovery from longstanding and severe eating disorders (EDs).
Background: The typically early age of onset, high incidence, and prolonged duration of EDs, has a high personal, relational, and financial burden for people who experience them. Current treatment practices rely on the exertion of external control and influence which has profound impacts on people living with EDs as well as the relationship and interactions between them and their treating professionals.
BMC Musculoskelet Disord
December 2024
Tarabichi Center for Joint Surgery, Al Zahra Hospital, Dubai, United Arab Emirates.
Introduction: Malrotation of the tibial components in total knee arthroplasties is a common cause of pain and functional impairment. There are multiple methods used to establish the tibial component rotation, but there is still no consensus which method is the best.The objective of this study was to compare two of the most commonly used techniques, that is the use of self-alignment during passive range of motion (free-floating technique) versus the anterior cortex referencing method (Curve-on-curve technique).
View Article and Find Full Text PDFJ Am Acad Orthop Surg
December 2024
From the Department of Orthopaedic Surgery (Chen, Liu, Gallo, Kusnezov, Chung, Christ, and Heckmann), and the Department of Radiology (Hwang), Keck School of Medicine of USC, Los Angeles, CA.
Subst Use Addctn J
December 2024
Department of Population and Quantitative Health Sciences, University of Massachusetts Chan Medical School, Worcester, MA, USA.
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