Objective: To evaluate the safety of vaccine by analyzing the death cases after vaccination.

Methods: To collect and analyze infomation of death cases related after vaccination in Shanghai during 2006-2008.

Results: In the 6 death cases reported after vaccination, 1 case was rare serious adverse events following immunization (AEFI), respiratory and circulatory failure caused by allergic disease. Other 5 cases were not related to vaccination.

Conclusions: Coincidental event is common type in death after vaccination. Monitoring adverse events following immunization is the key measure to deal with the death cases following immunization.

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