We describe a 6-year-old boy who developed Borrelia burgdorferi-associated lymphocytoma cutis on the ear. Lymphocytoma is a benign polyclonal B-cell lymphoproliferative process; it is defined as a subacute manifestation of early disseminated borrelial infection. Clinical history, physical examination, and serodiagnosis tests are often sufficient to establish diagnosis, but sometimes, histopathologic analysis is needed to exclude malignant cutaneous lymphomas. The outcome is always favorable but after antibiotic therapy, the lesion disappears promptly.
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http://dx.doi.org/10.1016/j.arcped.2010.05.004 | DOI Listing |
Am J Dermatopathol
March 2022
Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX; and.
Cutaneous lymphoid hyperplasia (CLH) is a benign reactive process with T-cell or B-cell lymphocytic infiltration in the skin, which can simulate cutaneous lymphomas both clinically and histologically. Various antigenic stimuli have been implicated in the development of CLH, including tick bites. Finding histologic evidence of such triggering factors, however, is often difficult.
View Article and Find Full Text PDFJ Cutan Pathol
April 2018
Departments of Dermatology and Pathology, University of Iowa Hospitals and Clinics, Iowa City, Iowa.
Lyme disease classically evolves through clinical manifestations according to the stage of illness. Because many of the systemic symptoms are non-specific, and because serology may yield false negative results, cutaneous findings merit even greater importance to diagnosis. The prototypical skin lesion, erythema migrans (EM), occurs early and is the only independent diagnostic clinical feature according to the guidelines of the Infectious Diseases Society of America.
View Article and Find Full Text PDFJ Am Acad Dermatol
April 2015
Dermatopathologie Friedrichshafen, Friedrichshafen, Germany.
Background: With the exception of erythema migrans, Borrelia infection of the skin manifests much more commonly with B cell-rich infiltrates. T cell-rich lesions have rarely been described.
Objective: We report a series of 6 patients with cutaneous borreliosis presenting with T cell-predominant skin infiltrates.
Am J Dermatopathol
May 2013
Research Unit of Dermatopathology, Department of Dermatology, Medical University of Graz, Graz, Austria.
In this study, we describe the clinicopathologic features of pseudolymphomatous infiltrates found within lesions of acrodermatitis chronica atrophicans (ACA). We studied 11 patients (10 females, 1 male, age range 60-88 years). The diagnosis of ACA in all cases was confirmed by clinicopathologic correlation and positive serology for Borrelia.
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