Desympathization of the uterus in albino rats increased the intensity of 3H-estradiol inclusion into its tissues, while division of the parasympathetic nerves on the contrary, reduced it. Both types of denervation prevent increase of the cAMP and cGMP content in the organ under the effect of estradiol. Thus, the neural influences and the effect of estradiol in the uterine tissues are related. Neuromediator mechanisms evidently play a role in realization of the late cAMP- and cGMP-dependent effects of estrogens.
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