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Massively parallel reporter assay investigates shared genetic variants of eight psychiatric disorders.
Cell
January 2025
Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Neuroscience Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. Electronic address:
A meta-genome-wide association study across eight psychiatric disorders has highlighted the genetic architecture of pleiotropy in major psychiatric disorders. However, mechanisms underlying pleiotropic effects of the associated variants remain to be explored. We conducted a massively parallel reporter assay to decode the regulatory logic of variants with pleiotropic and disorder-specific effects.
View Article and Find Full Text PDFEEG Signals Classification Related to Visual Objects Using Long Short-Term Memory Network and Nonlinear Interval Type-2 Fuzzy Regression.
Brain Topogr
January 2025
Department of Biomedical Engineering, Amirkabir University of Technology, Tehran, Iran.
By gaining insights into how brain activity is encoded and decoded, we enhance our understanding of brain function. This study introduces a method for classifying EEG signals related to visual objects, employing a combination of an LSTM network and nonlinear interval type-2 fuzzy regression (NIT2FR). Here, ResNet is utilized for feature extraction from images, the LSTM network for feature extraction from EEG signals, and NIT2FR for mapping image features to EEG signal features.
View Article and Find Full Text PDFCorrelated Decoding of Logical Algorithms with Transversal Gates.
Phys Rev Lett
December 2024
Department of Physics, Harvard University, Cambridge, Massachusetts 02138, USA.
Quantum error correction is believed to be essential for scalable quantum computation, but its implementation is challenging due to its considerable space-time overhead. Motivated by recent experiments demonstrating efficient manipulation of logical qubits using transversal gates [Bluvstein et al., Nature (London) 626, 58 (2024)NATUAS0028-083610.
View Article and Find Full Text PDFMulti-responsive biosensor prepared based on MXene and PDEA-HRP binary architecture films for HO detection and logic gate construction.
Talanta
April 2025
College of Public Health, School of Basic Medicine, Ningxia Medical University, Yinchuan, 750004, China. Electronic address:
The quantitative detection of HO is of great significance for preventing the occurrence of diseases. In this work, an electrochemical biosensor for detecting HO was constructed through a step-by-step modification method. The PDEA-HRP/MXene/PG biosensor (PDEA = poly(N,N-dimethyl acrylamide), HRP = horseradish peroxidase, PG = pyrolytic graphite) was prepared with two-dimensional metal carbide (MXene) nano materials as the inner layer and PDEA-HRP hydrogel as the outer layer for the detection of HO.
View Article and Find Full Text PDFThe convoluted path leading to neuronal circuit formation.
Curr Opin Neurobiol
December 2024
Department of Translational Neuroscience - University Medical Centre Utrecht Brain Center, Utrecht University, Utrecht, the Netherlands. Electronic address:
A limiting step of neuronal circuit formation is the extensive migration of interneurons from their birthplace to populate territories formed by excitatory neurons. Interneuron dynamics in the developing brain culminates with the organization of interneuron subtypes in specific configurations within layers of brain tissue. Decoding the logic behind these configurations is still matter of passionate debate.
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