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Severe Ethylene Glycol Toxicity: Multidisciplinary Management and Long-Term Renal Implications.
Cureus
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Internal Medicine, Griffin Hospital, Derby, USA.
Ethylene glycol (C₂H₆O₂), a toxic alcohol commonly found in automotive antifreeze, de-icing solutions, and industrial coolants, can cause severe toxicity when ingested. Due to its sweet taste, it is often consumed accidentally or intentionally, leading to life-threatening consequences such as metabolic acidosis, acute kidney injury (AKI), and mortality. Prompt diagnosis and early treatment with antidotes such as fomepizole or ethanol, combined with hemodialysis, are essential in preventing severe outcomes.
View Article and Find Full Text PDFCHAC1 Mediates Endoplasmic Reticulum Stress-Dependent Ferroptosis in Calcium Oxalate Kidney Stone Formation.
Adv Sci (Weinh)
January 2025
Department of Urology, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, 430060, P. R. China.
The initiation of calcium oxalate (CaOx) kidney stone formation is highly likely to stem from injury to the renal tubular epithelial cells (RTECs) induced by stimulation from an aberrant urinary environment. CHAC1 plays a critical role in stress response mechanisms by regulating glutathione metabolism. Endoplasmic reticulum (ER) stress and ferroptosis are demonstrated to be involved in stone formation.
View Article and Find Full Text PDFDefense to in groundnut ( L.) is associated with vascular tissue compactness and expression of genes coding for pathogenesis-related (PR) proteins.
3 Biotech
February 2025
Junagadh Agricultural University, Junagadh, Gujarat 362001 India.
Unlabelled: is the causal agent of stem rot of many crops, a highly destructive disease of groundnut ( L). Based on evidence that many groundnut genotypes have an inherent ability to tolerate the pathogenicity of species, twenty-two genotypes of groundnut were screened against infection in sick plot field experiment; four genotypes, namely CS19, GG16, GG20 and TG37A, were selected as being the most tolerant, moderately tolerant, susceptible and highly susceptible to stem rot, respectively. Stem tissues (1cm from the collar region) from infected and healthy plants of four selected genotypes differing in susceptibility were examined using a scanning electron microscope (SEM).
View Article and Find Full Text PDFCalcium oxalate crystals in cacao trees and their interactions with cadmium.
Plant Physiol Biochem
January 2025
Univ. Grenoble Alpes, Univ. Savoie Mont Blanc, CNRS, IRD, Univ. Gustave Eiffel, ISTerre, 38000, Grenoble, France.
Cadmium (Cd) concentrations in cacao beans from Latin America often exceed limits for trading. A better understanding of the mechanisms of Cd accumulation in Theobroma cacao L. trees is necessary to advance mitigation strategies.
View Article and Find Full Text PDFStability of lead immobilization by Aspergillus niger and fluorapatite under different pH conditions.
Ecotoxicol Environ Saf
January 2025
Anhui Province Engineering and Technology Research Center of Intelligent Manufacture and Efficient Utilization of Green Phosphorus Fertilizer, College of Resources and Environment, Anhui Agricultural University, Hefei 230036, PR China; Anhui Province Key Lab of Farmland Ecological Conservation and Pollution Prevention, College of Resources and Environment, Anhui Agricultural University, Hefei 230036, PR China; Key Laboratory of JiangHuai Arable Land Resources Protection and Eco-restoration, Ministry of Natural Resources, College of Resources and Environment, Anhui Agricultural University, Hefei 230036, PR China. Electronic address:
The combination of Aspergillus niger (A. niger) and fluorapatite (FAp) has been applied in lead (Pb) immobilization. However, the different pH can affect the stability of the immobilized Pb minerals.
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