Ten patients receiving propofol for the induction and maintenance of anaesthesia were compared with 10 patients in whom anaesthesia was induced with thyopentone and maintained with fentanil. The cardiovascular response to anaesthesia, the effects on coagulation and fibrinolysis and the neuroendocrine response have been investigated during surgical procedures exceeding 90'. There was a larger decrease in PA after induction in the propofol group versus control, but the overall quality of anaesthesia during induction and maintenance was comparable in both groups. No differences were found about blood coagulation and fibrinolysis between the groups. Important differences between the groups were instead found about the cortisol response to anaesthesia and surgery: in the propofol group there was a decrease in the cortisol concentration in 90' sample with no statistical significance, returning to the baseline value after 1 h from recovery. In the control group a significant increase of cortisol concentration was noted both at 90' and 1 h after the end of anaesthesia.
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