AI Article Synopsis
- A radiation sterilization dose (RSD) of 25 kGy is harmful to bone allografts, prompting a study to find a lower RSD using ISO 11137.2:2006 standards.
- The bioburden of the tested allografts was zero, allowing for a verification dose of 1.3 kGy, which was tested by irradiating 100 allografts.
- The study concluded that an RSD of 11 kGy is effective for ensuring sterility (10(-6) assurance level) in bone allografts with low bioburden.
Article Abstract
A radiation sterilization dose (RSD) of 25 kGy is deleterious to bone allografts. This study aimed to establish a lower RSD for bone allografts using method 1 of International Standard Organisation 11137.2:2006. This provides a database to select an RSD corresponding to an allograft's bioburden, given that the bioburden's gamma resistance is equal to or less than the standard. This can be verified by irradiating 100 allografts at a dose selected to provide a sterility assurance level of 10(-2). The bioburden of our allografts was 0, which prescribed a verification dose of 1.3 kGy. After irradiating 100 allografts, sterility tests returned no positive cultures. We therefore validated an RSD of 11 kGy for allografts with that bioburden. According to the standard, this RSD provides a sterility assurance level of 10(-6) for bone allografts.
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| http://dx.doi.org/10.1016/j.arth.2010.03.032 | DOI Listing |
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