AI Article Synopsis
- Exemestane is a medicine that helps lower estrogen levels in postmenopausal women, which is important for treating certain types of breast cancer.
- This review looks at research from 1988 to now to show how well exemestane works and how it can be used for patients with estrogen-receptor-positive breast cancer.
- The main takeaway is that exemestane is a helpful and safe option for treating early-stage and advanced breast cancer after using another medicine called tamoxifen for a couple of years.
Article Abstract
Importance Of The Field: Inhibition of the aromatase enzyme in postmenopausal women reduces levels of estrogens, which is of therapeutic value in hormone-sensitive breast cancer. Exemestane is a third-generation steroidal irreversible inactivator of the aromatase enzyme used in early and advanced breast cancer for the treatment of postmenopausal women with estrogen-receptor-positive disease.
Areas Covered In This Review: The scientific literature on exemestane, including published articles and abstracts, was searched from 1988 to the present, and the most significant results are included in the review.
What The Reader Will Gain: The review outlines the pharmacological characteristics of exemestane and the evidence supporting its use in the treatment of postmenopausal women with early or advanced estrogen-receptor-positive breast cancer.
Take Home Message: Exemestane is an effective and well-tolerated aromatase inhibitor with a defined role in early-stage breast cancer following 2 - 3 years of adjuvant treatment with tamoxifen. Exemestane also has a role in the sequence of hormonal agents employed to control advanced hormone-sensitive breast cancer, in which clinicians may exploit its partial lack of cross-resistance with nonsteroidal aromatase inhibitors.
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| http://dx.doi.org/10.1517/14656566.2010.495945 | DOI Listing |
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