Men and women 70-79 yr of age (N = 49) were studied to assess the effect of 6 months of resistance or endurance exercise training on their blood pressure, hemodynamic parameters, and pressor hormone levels. Resistance training consisted of one set of 8-12 repetitions on ten Nautilus machines three times per week. The endurance training group progressed to training at 75-85% VO2max for 35-45 min three times per week for the last 2 months of training. No changes in body weight or estimated lean body mass occurred; however, the sum of seven skinfolds, as an index of percent body fat, decreased in both exercise groups. Upper and lower body strength increased with resistance training, while VO2max increased by 20% in the endurance training group. Blood pressure did not change with resistance training in individuals with normal or somewhat elevated blood pressures. Diastolic and mean blood pressure decreased significantly, by 5 and 4 mm Hg, with endurance training. Subjects with blood pressure greater than 140/90 reduced their systolic, diastolic, and mean blood pressure by 8, 9, and 8 mm Hg, respectively, with endurance exercise training. Cardiac output, peripheral vascular resistance, and plasma levels of angiotensin I and II and epi- and norepinephrine did not change in any of the groups. Thus, resistance exercise training does not adversely affect, or reduce, blood pressure, while endurance exercise training produces modest reductions in blood pressure in 70-79-yr-old individuals with somewhat elevated blood pressures.
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BMC Nephrol
December 2024
Head Doctor of the Dialysis Medical Center LLC, "Nephrocenter", Dovzhenka 3, Kyiv, 03057, Ukraine.
Background: The impact of protein-bound uremic toxins, specifically indoxyl sulfate (IS) on peritoneal dialysis (PD) complications remains controversial. This study aimed to explore the link between serum total IS (tIS) levels, proinflammatory cytokines in serum and peritoneal dialysis effluent (PDE), and PD technique survival.
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BMC Public Health
December 2024
Muhimbili University of Health and Allied Sciences, Dar es salaam, United Republic of Tanzania.
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View Article and Find Full Text PDFHipertens Riesgo Vasc
December 2024
Facultad de Ciencias Médicas, Universidad Nacional de La Plata, Argentina; Centro de Investigaciones Cardiovasculares "Dr. Horacio E. Cingolani" CONICET-UNLP, Argentina. Electronic address:
Background: Blood pressure (BP) is linearly related to the incidence of cardiovascular disease from values as low as 115/75mmHg, even at young ages. A particularly concerning issue is the decrease representation of optimal BP among children and youth. The mechanisms by which minimal elevations in BP increase cardiovascular risk are not defined.
View Article and Find Full Text PDFVet Anaesth Analg
December 2024
Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, CA, USA.
Objective: To characterize the anesthetic effects of dexmedetomidine, vatinoxan and ketamine combinations in cats.
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Life Sci
December 2024
Department of Pharmacology, Cardiac & Cerebral Vascular Research Center, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou 510080, China. Electronic address:
Aims: Impairment of nitric oxide (NO) production is a major cause of endothelial dysfunction and hypertension. ClC-5 Cl channel is abundantly expressed in the vascular endothelium. However, it remains unclear how it regulates endothelial function.
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