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LOX-induced tubulointerstitial fibrosis via the TGF-β/LOX/Snail axis in diabetic mice.
J Transl Med
January 2025
Department of Basic Medical Sciences, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310058, China.
Background: The partial epithelial-mesenchymal transition (EMT) is emerging as a significant mechanism in diabetic nephropathy (DN). LOX is a copper amine oxidase conventionally thought to act by crosslinking collagen. However, the role of LOX in partial EMT and fibrotic progression in diabetic nephropathy has not been investigated experimentally.
View Article and Find Full Text PDFMachine learning boosts wind turbine efficiency with smart failure detection and strategic placement.
Sci Rep
January 2025
Department of Communications and Electronics, Delta Higher Institute of Engineering and Technology, Mansoura, 35111, Egypt.
The research study objective seeks to improve the efficiency of wind turbines using state-of-the-art techniques in the domain of ML, making wind energy the key player in fashioning a favorable future. Wind Turbine Health Monitoring (WTHM) is typically achieved through either vibration analysis or by using Supervisory Control and Data Acquisition (SCADA) data of wind turbines, wherein conventional fault pattern identification is a time-consuming, guesswork process. This work proposed an intelligent automated approach to early fault detection through the implementation of the HARO (Huber Adam Regression Optimizer) model, which combines Transformer networks with Lasso Regression and the Adam optimizer.
View Article and Find Full Text PDFFactors influencing individuals to move away from careers as clinical radiographers.
Radiography (Lond)
January 2025
Radiography and Diagnostic Imaging Section, School of Medicine, University College Dublin, Dublin, Ireland. Electronic address:
Introduction: Many factors can influence a radiographer to leave the clinical profession. The retention of radiographers in the clinical workforce is an issue for many countries including Ireland. This study aimed to explore factors influencing radiographers in Ireland to leave the clinical profession so that changes can be considered to reduce attrition from clinical workforce.
View Article and Find Full Text PDFExploratory Factor Analysis of the Moulage Authenticity Rating Scale and Proposed Adaptations.
J Nurs Meas
January 2025
Computer Science and Informatics, University of the Free State, Bloemfontein, South Africa
Moulage plays an important part in enhancing simulation-based learning experience fidelity; however, limited tools exist to measure the fidelity of moulage. The original Moulage Authenticity Rating Scale (MARS) is a possible tool to determine moulage's physical and conceptual fidelity in simulation. Although the MARS was proven reliable and valid in the original context, the authors sought to validate it in South Africa.
View Article and Find Full Text PDFASPIRIN-TRIGGERED LIPOXIN A4 REDUCES NEUROPATHIC PAIN AND ANXIETY-LIKE BEHAVIOURS IN MALE DIABETIC RATS: ANTINOCICEPTIVE ENHANCEMENT BY CANNABINOID RECEPTOR AGONISTS.
Eur J Pharmacol
January 2025
Laboratory of Pharmacology of Pain, Department of Pharmacology, Federal University of Paraná, Curitiba, PR, Brazil.
Neuropathy is the most common complication of diabetes, leading to painful symptoms like hyperalgesia. Current treatments for diabetic painful neuropathy often prove inadequate, necessitating the exploration of new pharmacological approaches. Therefore, this study aimed to investigate the potential antinociceptive effect of aspirin-triggered lipoxin A4 (ATL), a specialized pro-resolving lipid mediator, when administered alone or in combination with cannabinoid agonists, to alleviate diabetic neuropathic pain.
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