Background: Insulin-like growth factor (IGF-1) has been associated with cardiovascular disease, hypertension and diabetes in previous studies. However, the association between IGF-1 and chronic kidney disease (CKD) has not been previously studied. Therefore, we examined the association between serum IGF-1 and CKD in a representative sample of US adults.
Methods: We conducted a cross-sectional study of 5388 Third National Health and Nutrition Examination Survey (NHANES III) participants aged ≥20 years of age (55.2% women). Serum IGF-1 was categorized into quartiles for the analysis. CKD (n = 241) was defined as an estimated glomerular filtration rate of <60 mL/min/1.73/m(2).
Results And Conclusion: Higher serum IGF-1 levels were positively associated with CKD after adjusting for age, sex, race/ethnicity, education levels, smoking, alcohol intake, body mass index, diabetes, hypertension and serum cholesterol. Compared to quartile 1 of IGF-1 (referent), the odds ratio (95% confidence interval) of CKD associated with quartile 4 was 2.66 (1.18-5.99); p trend = 0.008. Subgroup analysis that examined the relation between IGF-1 and CKD by gender showed a consistent positive association. In summary, increasing levels of serum IGF-1 were positively associated with CKD in a representative sample of US adults. Our results suggest that IGF-1 might be a predictor of CKD in Western populations.
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