AI Article Synopsis

  • * In September 2007, she faced multiple liver metastases, leading to a change in her chemotherapy regimen to include S-1 and paclitaxel, with dosage adjustments due to side effects like reduced appetite and leukocyte counts.
  • * By March 2009, follow-up CT scans showed no liver metastases, and she achieved continuous clinical remission while undergoing outpatient treatment, highlighting the potential of the S-1/paclitaxel combination for future clinical trials in recurrent breast cancer.

Article Abstract

The case is a woman in her 50's. A total glandectomy was performed for her breast cancer on August 8, 1998, and subsequently chemotherapy(5'-DFUR, CMF, uracil.tegafur, CEF, and docetaxel)as well as radiation therapy and surgical resection have been performed for local recurrence. With multiple hepatic metastasis recognized in September, 2007, chemotherapy combined with S-1/paclitaxel(PTX)has been performed. In view of the side effects such as reduction in appetite and leukocyte, the dosage has been reduced as of the second course of treatment. With the disappearance of hepatic metastasis on CT, 6 courses of S-1monotherapy have been performed after completing 6 courses of chemotherapy combined with S-1/ PTX. As of March, 2009, the therapeutic effect shows that continuous CR and outpatient follow-up have been performed while maintaining QOL. Since any chemotherapy after thirdline treatment for recurrent breast cancer has not been established yet, chemotherapy combined with S-1/PTX is considered to be one of the regimens and therefore, the second and thirdphase clinical tests ahead are expected to bring better outcomes.

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