AI Article Synopsis
- The CloneSelect Imager is an advanced imaging system designed to assess cell growth, offering a modern alternative to the traditional MTT assay.
- Both systems produced similar results in determining the effectiveness of cisplatin and oxaliplatin on different cell lines, but the CloneSelect Imager proved to be faster, more accurate, and non-invasive.
- This new imaging technique shows promise for replacing the MTT assay in scenarios requiring quick and high-throughput cytotoxicity testing.
Article Abstract
Background: The CloneSelect Imager system is an image-based visualisation system for cell growth assessment. Traditionally cell proliferation is measured with the colorimetric MTT assay.
Results: Here we show that both the CloneSelect Imager and the MTT approach result in comparable EC50 values when assaying the cytotoxicity of cisplatin and oxaliplatin on various cell lines. However, the image-based technique was found non-invasive, considerably quicker and more accurate than the MTT assay.
Conclusions: This new image-based technique has the potential to replace the cumbersome MTT assay when fast, unbiased and high-throughput cytotoxicity assays are requested.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2906423 | PMC |
| http://dx.doi.org/10.1186/1472-6750-10-43 | DOI Listing |
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