Aim: To evaluate the effect of the I(f) channel blocker ivabradine on bronchial patency and the volume parameters of external respiration function in patients with chronic obstructive pulmonary disease (COPD) in remission in order to determine whether the drug may be used in patients with coronary heart disease (CHD) concurrent with COPD.
Subjects And Methods: Heart rate, bronchial patency, and lung volume were studied by body plethysmography in 59 patients with COPD before and 14 days after administration of ivabradine in a daily dose of 10 mg.
Results: The I(f) channel blocker ivabradine that is a highly selective bradycardiac agent fails to affect the velocity and volume parameters of external respiration function, thus it may be used to treat CHD concurrent with COPD.
Conclusion: The I(f) channel blocker ivabradine exerts no effect on external respiration function parameters (bronchial patency, volume parameters) and it can find clinical use in the treatment of angina pectoris and chronic heart failure in patients with CHD concurrent with COPD.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Synergistic antibacterial effects of pinaverium bromide and oxacillin against .
Zhong Nan Da Xue Xue Bao Yi Xue Ban
October 2024
Department of Laboratory Medicine, Third Xiangya Hospital, Central South University, Changsha 410013, China.
Objectives: () adheres to the surface of medical devices, forming highly drug-resistant biofilms, which has made the development of novel antibacterial agents against and its biofilms a key research focus. By drug repurposing, this study aims to explore the combinational antimicrobial effects between pinaverium bromide (PVB), a -type calcium channel blocker, and oxacillin (OXA) against .
Methods: Clinical isolates of were collected from January to September 2022 at the Department of Clinical Laboratory of the Third Xiangya Hospital, Central South University.
Mammalian TMC1 or 2 are necessary for scramblase activity in auditory hair cells.
Hear Res
March 2025
Boston Children's Hospital and Harvard Medical School, 300 Longwood Ave, Boston, MA 02115, USA. Electronic address:
Sensory transduction in auditory hair cells gates mechanosensitive ion channels, converting sound information into electrical signals (Zheng and Holt, 2021). Previously, we found that Transmembrane channel (TMC) proteins 1 and 2 form the pore of hair cell transduction channels (Pan et al., 2013; 2018).
View Article and Find Full Text PDFEffects of Blocking Multiple Sources of Calcium in Hippocampus During Spatial Learning and Memory Using a Rapid Acquisition Variant of the Morris Water Task.
Hippocampus
March 2025
Canadian Centre for Behavioural Neuroscience, The University of Lethbridge, Lethbridge, Alberta, Canada.
Long-term potentiation (LTP) is proposed to be the molecular mechanism underlying learning and memory in the brain. A key event for LTP is the influx of calcium into post-synaptic neurons via multiple ion channel control systems. One such system involves N-methyl-D-aspartate receptors (NMDARs), which were originally believed to be essential for LTP and new learning.
View Article and Find Full Text PDFEXPRESS: Exploring Novel Non-Opioid Pathways and Therapeutics for Pain Relief.
Mol Pain
March 2025
Trauma Research, Swedish Medical Center, Englewood, Colorado, United States of America.
The opioid crisis has highlighted the urgent need for alternative pain management strategies. This review explores novel non-opioid targets and pathways involved in pain modulation, highlighting advancements in understanding and therapeutic potential. Pain, a multifaceted phenomenon with nociceptive, neuropathic, and inflammatory components, involves intricate molecular signaling cascades.
View Article and Find Full Text PDFDrug-associated gingival disorders: a retrospective pharmacovigilance assessment using disproportionality analysis.
BDJ Open
March 2025
Bahrain Defence Force Royal Medical Services, Riffa, Kingdom of Bahrain.
Background: Drug-associated gingival disorders can negatively impact on oral health. This study aimed to utilize the United States Food and Drug Administration Adverse Event Reporting System (USFDA AERS) to comprehensively assess the associations between medications and specific gingival disorders.
Methods: Data were extracted from the USFDA AERS from 2004-2024 using Preferred Terms for eight gingival disorders.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!