This work presents a new approach toward a fast, simultaneous amplitude of radiofrequency field (B(1)) and T(1) mapping technique. The new method is based on the "actual flip angle imaging" (AFI) sequence. However, the single pulse repetition time (TR) pair used in the standard AFI sequence is replaced by multiple pulse repetition time sets. The resulting method was called "multiple TR B(1)/T(1) mapping" (MTM). In this study, MTM was investigated and compared to standard AFI in simulations and experiments. Feasibility and reliability of MTM were proven in phantom and in vivo experiments. Error propagation theory was applied to identify optimal sequence parameters and to facilitate a systematic noise comparison to standard AFI. In terms of accuracy and signal-to-noise ratio, the presented method outperforms standard AFI B(1) mapping over a wide range of T(1). Finally, the capability of MTM to determine T(1) was analyzed qualitatively and quantitatively, yielding good agreement with reference measurements.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/mrm.22333 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Hypothalamic volume is associated with age, sex and cognitive function across lifespan: a comparative analysis of two large population-based cohort studies.
EBioMedicine
January 2025
Population Health Sciences, German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany; Department of Neurology, Faculty of Medicine, University of Bonn, Germany. Electronic address:
Background: Emerging findings indicate that the hypothalamus, the body's principal homeostatic centre, plays a crucial role in modulating cognition, but comprehensive population-based studies are lacking.
Methods: We used cross-sectional data from the Rhineland Study (N = 5812, 55.2 ± 13.
Evaluation of an electronic clinical decision support algorithm to improve primary care management of acute febrile illness in rural Cambodia: protocol for a cluster-randomised trial.
BMJ Open
October 2024
Mahidol Oxford Tropical Medicine Research Unit, Bangkok, Thailand.
Introduction: Acute febrile illness (AFI), traditionally attributed to malaria, is a common reason for seeking primary healthcare in rural South and Southeast Asia. However, malaria transmission has declined while health workers are often poorly equipped to manage non-malarial AFIs. This results in indiscriminate antibiotic prescribing and care escalation, which promotes antibiotic resistance and may increase healthcare costs.
View Article and Find Full Text PDFCapivasertib and fulvestrant for patients with HR-positive/HER2-negative advanced breast cancer: analysis of the subgroup of patients from Japan in the phase 3 CAPItello-291 trial.
Breast Cancer
January 2025
Tokyo Metropolitan Cancer and Infectious Disease Center, Komagome Hospital, Tokyo, Japan.
Article Synopsis
- - In the CAPItello-291 study, capivasertib combined with fulvestrant showed improved progression-free survival (PFS) compared to placebo in patients with advanced HR-positive/HER2-negative breast cancer, including those with specific genetic alterations (PIK3CA, AKT1, or PTEN).
- - Among the 708 total patients, 78 were from Japan, where results also indicated a numerical PFS benefit for the capivasertib-fulvestrant group, suggesting consistency with global findings.
- - The safety profile for the Japanese subgroup was similar to that of the worldwide population, indicating no new safety concerns, thus supporting the efficacy of the treatment approach.
Comprehensive Investigation of Homology and Heterogeneity Between Aurantii Fructus and Aurantii Fructus Immaturus Using Chemometrics Combined with Network Pharmacology.
J Med Food
November 2024
School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin, China.
Aurantii Fructus (AF) and Aurantii Fructus Immaturus (AFI) are distinct herbs outlined by the Chinese Pharmacopoeia. They are sourced from the same plant but harvested at different times, resulting in differences in efficacy. It is important to avoid mixing them clinically and to distinguish between the two.
View Article and Find Full Text PDFAFI manual planning versus HyperArc auto-planning: A head-to-head comparison of SRS plan quality.
J Appl Clin Med Phys
November 2024
Department of Radiation Medicine, University of Kentucky Chandler Medical Center, Lexington, Kentucky, USA.
Article Synopsis
- HyperArc (HA) auto-planning simplifies the creation of high-quality Stereotactic Radiosurgery (SRS) plans, while the "Ask For It" (AFI) manual planning method also aims for low intermediate dose spill and high target dose conformity.
- A comparison using 54 created target volumes (PTVs) showed both AFI and HA methods were used across a variety of case complexities to evaluate treatment plan quality.
- Results revealed that AFI outperformed HA in several quality metrics, although HA provided better dose coverage, suggesting both methods can yield effective planning outcomes.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!