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[Fe(µ-OH)] Linked FeO Triads: Mössbauer Evidence for Trigonal µ-O or µ-OH Groups in Bridged versus Unbridged Complexes.
Molecules
July 2024
School of Natural Sciences, Massey University, Private Bag 11 222, Palmerston North 4442, New Zealand.
The syntheses, coordination chemistry, and Mössbauer spectroscopy of hepta-iron(III) complexes using derivatised salicylaldoxime ligands from two categories; namely, 'single-headed' (H) and 'double-headed' (H) salicylaldoximes are described. All compounds presented here share a [Fe-µ-O] core in which the iron(III) ions are µ-hydroxo-bridged in the complex and µ-oxo-bridged in and . Each compound consists of 2 × [Fe-µ-O] triads that are linked via a central [Fe(µ-OH)] ion.
View Article and Find Full Text PDFDominant suppressor genes of p53-induced apoptosis in Drosophila melanogaster.
G3 (Bethesda)
September 2024
Institute of Genetics, HUN-REN Biological Research Centre, 6726 Szeged, Hungary.
One of the major functions of programmed cell death (apoptosis) is the removal of cells that suffered oncogenic mutations, thereby preventing cancerous transformation. By making use of a Double-Headed-EP (DEP) transposon, a P element derivative made in our laboratory, we made an insertional mutagenesis screen in Drosophila melanogaster to identify genes that, when overexpressed, suppress the p53-activated apoptosis. The DEP element has Gal4-activatable, outward-directed UAS promoters at both ends, which can be deleted separately in vivo.
View Article and Find Full Text PDFEssential dextrin structure as donor substrate for 4-α-glucanotransferase in glycogen debranching enzyme.
J Biochem
July 2024
Department of Chemistry, Graduate School of Science, Osaka Prefecture University, Gakuen-cho 1-1, Naka-ku, Sakai, Osaka 599-8531, Japan.
Glycogen debranching enzyme is a single polypeptide with distinct catalytic sites for 4-α-glucanotransferase and amylo-α-1,6-glucosidase. To allow phosphorylase to degrade the inner tiers of highly branched glycogen, 4-α-glucanotransferase converts the phosphorylase-limit biantennary branch G-G-G-G-(G-G-G-G↔)G-G- (G: d-glucose, hyphens: α-1,4-linkages; double-headed arrow: α-1,6-linkage) into the G-G-G-G-(G↔)G-G- residue, which is then subjected to amylo-α-1,6-glucosidase to release the remaining G↔ residue. However, while the essential side-chain structure of the 4-α-glucanotransferase donor substrate has been determined to be the G-G-G-G↔ residue (Watanabe, Y.
View Article and Find Full Text PDFFunctional and structural significance of the inner-arm-dynein subspecies d in ciliary motility.
Cytoskeleton (Hoboken)
November 2024
Department of Biological Sciences, Graduate School of Science, Osaka University, Osaka, Japan.
Motile cilia play various important physiological roles in eukaryotic organisms including cell motility and fertility. Inside motile cilia, large motor-protein complexes called "ciliary dyneins" coordinate their activities and drive ciliary motility. The ciliary dyneins include the outer-arm dyneins, the double-headed inner-arm dynein (IDA f/I1), and several single-headed inner-arm dyneins (IDAs a, b, c, d, e, and g).
View Article and Find Full Text PDFTail Length and E525K Dilated Cardiomyopathy Mutant Alter Human β-Cardiac Myosin Super-Relaxed State.
bioRxiv
December 2023
Department of Molecular Physiology and Biophysics, Cardiovascular Research Institute, University of Vermont, Burlington, Vermont.
Dilated cardiomyopathy (DCM) is characterized by impaired cardiac function due to myocardial hypo-contractility and is associated with point mutations in β-cardiac myosin, the molecular motor that powers cardiac contraction. Myocardial function can be modulated through sequestration of myosin motors into an auto-inhibited "super relaxed" state (SRX), which is further stabilized by a structural state known as the "Interacting Heads Motif" (IHM). Therefore, hypo-contractility of DCM myocardium may result from: 1) reduced function of individual myosin, and/or; 2) decreased myosin availability due to increased IHM/SRX stabilization.
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