AI Article Synopsis
- Researchers are using animal mammary glands to produce therapeutic human proteins.
- There is significant variability in how effectively these proteins are produced across different animals.
- The study explores whether factors like codon usage and protein structure might explain these differences in production efficiency.
Article Abstract
Animal mammary glands have been successfully employed to produce therapeutic recombinant human proteins. However, considerable variation in animal mammary transgene expression efficiency has been reported. We now consider whether aspects of codon usage and/or protein tertiary structure underlie this variation in mammary transgene expression.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2902731 | PMC |
| http://dx.doi.org/10.1007/s11248-010-9411-8 | DOI Listing |
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