We present several optical interconnection structures which support communication requirements unique to multiprocessor systems, namely, broadcasting, multicasting, simulcasting, and multiport memory access. The structures are based on guided wave time division multiplexed channels and use coincident pulse techniques to optically demultiplex individual bits at selected destinations. We describe 1-and 2-D structures which are appropriate for processor to processor interconnections and for processor to memory interconnections, respectively.
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http://dx.doi.org/10.1364/AO.29.002024 | DOI Listing |
J Neurophysiol
January 2025
Klab4Recovery SCI Research Program, The City University of New York, New York, USA.
The phase-dependent modulation pattern of the tibialis anterior (TA) flexion reflex was characterized during treadmill walking while transspinal stimulation was delivered at 15, 30, and 50 Hz above and below paresthesia in healthy participants. The flexion reflex was elicited following medial arch foot stimulation with a 30 ms (300 Hz) pulse train. During treadmill walking, the flexion reflex was evoked in the right leg every 3 to 5 steps, and stimuli were randomly dispersed across the step cycle that was divided into 16 equal bins.
View Article and Find Full Text PDFProc Natl Acad Sci U S A
January 2025
Department of Psychology, University of York, York YO10 5DD, United Kingdom.
Sleep disturbances are associated with intrusive memories, but the neurocognitive mechanisms underpinning this relationship are poorly understood. Here, we show that sleep deprivation disrupts prefrontal inhibition of memory retrieval, and that the overnight restoration of this inhibitory mechanism is associated with time spent in rapid eye movement (REM) sleep. The functional impairments arising from sleep deprivation are linked to a behavioral deficit in the ability to downregulate unwanted memories, and coincide with a deterioration of deliberate patterns of self-generated thought.
View Article and Find Full Text PDFBackground: Loss of stromal interaction molecule 1 (STIM1) expression in smooth muscle cells protects against ischemia-reperfusion (I/R) injury. Whether and how decreased STIM1 expression in cardiomyocytes (CM) impacts cardiac remodeling in response to I/R injury remains unknown.
Objective: To examine mechanisms by which decreased CM-STIM1 expression in the adult heart modulates cardiac function before and after I/R injury.
Am J Physiol Heart Circ Physiol
February 2025
Performance Science, WHOOP Inc., Boston, Massachusetts, United States.
Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) were originally developed for the treatment of type 2 diabetes but have recently been approved for chronic weight management and reducing cardiovascular risk in individuals with overweight and obesity. Despite this approval, significant heterogeneity in the cardioprotective benefits and less desirable increases in resting heart rate (RHR) with GLP-1 RAs have been reported. To better understand cardiovascular responses to GLP-1 RAs and the potential role of health behaviors in influencing these responses, we leveraged wearable technology and causal inference analysis.
View Article and Find Full Text PDFHear Res
December 2024
Neuroscience Graduate Program, University of Colorado School of Medicine, Aurora, CO 80045, USA; Department of Physiology and Biophysics, University of Colorado School of Medicine, Aurora, CO 80045, USA. Electronic address:
Noise-induced cochlear synaptopathy has been studied for over 25 years with no known diagnosis for this disorder in humans. This type of "hidden hearing loss" induces a loss of synapses in the inner ear but no change in audiometric thresholds. Recent studies have shown that by two months post synaptopathy-inducing noise exposure, synapses in some animal species can regenerate.
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