Genetically encoded protein photosensors are promising tools for engineering optical control of cellular behavior; we are only beginning to understand how to couple these light detectors to effectors of choice. Here we report a method that increases the dynamic range of an artificial photoswitch based on the LOV2 domain of Avena sativa phototropin 1 (AsLOV2). This approach can potentially be used to improve many AsLOV2-based photoswitches.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2914111 | PMC |
| http://dx.doi.org/10.1038/nmeth.1473 | DOI Listing |
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