AI Article Synopsis
- The study investigated YIGSR peptide anchored pegylated nanospheres (YIGSR-SN) loaded with 5-fluorouracil (5-FU) for targeted delivery to tumor-associated endothelial cells, achieving better selectivity compared to non-peptide nanospheres.
- YIGSR-SN showed significantly higher binding to endothelial cells and effectively reduced lung metastasis and angiogenesis in experimental models compared to free 5-FU and non-targeted nanospheres.
- Therapeutic trials indicated that YIGSR-SN led to greater tumor regression in mice, suggesting their potential as a targeted cancer treatment.
Article Abstract
YIGSR peptide anchored pegylated nanospheres (YIGSR-SN) loaded with 5-fluorouracil (5-FU) were investigated for selective and preferential presentation of carrier contents at angiogenic endothelial cells over-expressing laminin receptors on and around tumor tissue and thus for assessing their targetability. Pegylated nanosphere (SN) without peptide conjugate were used for comparison. The average size of all nanosphere preparations prepared was approximately 108 nm and maximum drug entrapment was 68.5 +/- 5.2%. In vitro endothelial cell binding of nanospheres exhibited 8-fold higher binding of YIGSR-SN to HUVEC in comparison to the SN. Spontaneous lung metastasis and angiogenesis assays show that YIGSR peptide anchored nanospheres are significantly (p
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http://dx.doi.org/10.3109/10717544.2010.490249 DOI Listing Publication Analysis
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