A formula (KSS formula) containing the pith of Citrus tangerine Hort. et Tanaka (Kitsuraku), the rhizome of Zingiber officinale (Shokyo), and brown sugar has been traditionally used in China for the treatment of discomfort and cold sensation in the abdomen after ingestion of large amounts of alcohol. We evaluated the clinical effectiveness of this formula on signs and symptoms of alcohol hangover (AH). Of the twenty-two symptoms listed, significant decreases in severity scores were shown in nausea, vomiting, and diarrhea when the formula was administered in scheduled prophylactic doses. The score in overall well-being, ranging from 0 to 100 (worst possible condition), was 68.9 +/- 16.5 (mean +/- SD) in the control group and it decreased to 46.9 +/- 27.3 and to 44.4 +/- 26.4 in the two groups that included a dosing point prior to alcohol ingestion. Regardless of dosing schedules, KSS formula did not alter the time required for complete recovery from AH symptoms. These findings suggest the possibility that KSS formula may become a candidate for AH remedy when administered prophylactically.
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http://dx.doi.org/10.1007/s11418-010-0430-9 | DOI Listing |
BMC Biol
February 2023
Department of Clinical Sciences, Pediatrics, Umeå University, Umeå, 901 85, Sweden.
Brain Res
October 2021
Department of Applied Pharmacology, Graduate School of Medical and Dental Sciences, Kagoshima University, 8-35-1 Sakuragaoka, Kagoshima 890-8544, Japan. Electronic address:
BMC Musculoskelet Disord
April 2021
Department of Orthopaedic Surgery, Yokohama City University Graduate School of Medicine, 3-9, Fukuura, Kanazawa-ku, Yokohama, 236-0004, Japan.
Background: Rehabilitation is an effective procedure for promoting functional recovery after simultaneous bilateral total knee arthroplasty (TKA); however, it has been cited as a significant economic burden of medical care. We hypothesized that preoperative factors, including age, sex, body mass index, living alone, the knee society function score (KSS), the American society of anesthesiologists (ASA) class, hemoglobin (Hb), albumin level, mean range of motion, and the Kellgren-Lawrence grade, would predict prolonged rehabilitation utilization.
Methods: In total, 191 patients undergoing simultaneous bilateral TKA in a single hospital were enrolled.
The ability to monitor neurochemical dynamics in target brain regions with a high degree of temporal resolution has assisted researchers in investigating the pathogenesis, and pathophysiology of a variety of neurological and psychiatric disorders. Current systems for neurochemical monitoring are bulky or expensive, limiting widespread exploration of this research field and preventing large-scale parallel experimentation. In this paper, we present a new miniaturized research platform, the TinyFSCV system, which can be used to monitor dynamic changes in neurochemicals through Fast-Scan Cyclic Voltammetry (FSCV).
View Article and Find Full Text PDFJ Ethnopharmacol
May 2019
Institute of Natural Medicine, University of Toyama, 2630 Sugitani, Toyama, 930-0194, Japan.
Ethnopharmacological Relevance: Kami-shoyo-san (KSS) is a Kampo formula used clinically for menopause-related symptoms in Japan. However, the effect of KSS on autism spectrum disorder (ASD), a developmental disorder with a higher prevalence in males than in females, has not been reported yet.
Aim Of The Study: It is accepted generally that dysfunction in the GABAergic system is associated with pathogenesis of ASD.
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