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The European Drug-Drug Interaction (EuroDDI) Study Protocol: A Cross-Country Comparison of Drug-Drug Interaction Prevalence in the Older Community-Dwelling Population.
Pharmacoepidemiol Drug Saf
January 2025
School of Population Health, RCSI University of Medicine and Health Sciences, Dublin 2, Ireland.
Background: Drug-drug interactions (DDIs), highly prevalent amongst the elderly, can lead to avoidable medication-related harm. Cardiovascular and central nervous system (CNS) drugs are commonly implicated. To date, there is no consensus on how to measure DDIs, making comparisons across countries challenging.
View Article and Find Full Text PDFCommentary on "Social protection and the International Monetary Fund: promise versus performance" by Alexander Kentikelenis and Thomas Stubbs.
Global Health
January 2025
Department of Global Health Hans Rosling Center, University of Washington, 3980 15th Ave NE, Seattle, Seattle, WA, 98105, USA.
Background: The Covid pandemic and its aftermath have triggered new alarm and social unrest across the Global South over the deepening international debt crisis that now threatens to derail Universal Health Coverage (UHC), other Sustainable Development Goals (SDGs), future pandemic preparedness, and global warming mitigation. The recent Globalization and Health article by Alex Kentikelenis and Thomas Stubbs (May 2024), "Social protection and the International Monetary Fund: promise versus performance", offers a meticulously quantified rendering of the social costs imposed by the crisis and takes aim at IMF solutions. They advocate for a rejection of IMF austerity programs and offer a valuable prescription for change through the International Labor Organization's "Universal Social Protection" concept.
View Article and Find Full Text PDFIntergovernmental or fully independent? Designing a scientific panel on evidence for action against antimicrobial resistance.
PLOS Glob Public Health
January 2025
Global Strategy Lab, Dahdaleh Institute for Global Health Research, York University, Toronto, Ontario, Canada.
Article Synopsis
- Effective global action against antimicrobial resistance (AMR) requires a robust scientific policy interface to translate evidence into practice, an area currently lacking an authoritative entity.
- The proposed Scientific Panel on Evidence for Action against AMR (SPEA) aims to fill this gap by enhancing global coordination, providing real-time evidence, and tracking progress towards AMR goals.
- Drawing lessons from the Intergovernmental Panel on Climate Change (IPCC), this essay discusses the potential functions and governance models for SPEA to support equitable, evidence-informed policy-making while addressing inherent challenges.
Cohesin positions the epigenetic reader Phf2 within the genome.
EMBO J
January 2025
Research Institute of Molecular Pathology (IMP), Vienna Biocenter (VBC), Campus-Vienna-Biocenter 1, 1030, Vienna, Austria.
Article Synopsis
- Genomic DNA is organized into chromatin with the help of histones and cohesin, but their cooperation in genome regulation is not well understood.
- Researchers identified Phf2, a histone demethylase, as a protein that interacts with cohesin, indicating a potential role in regulating transcription at active gene sites.
- The studies show that Phf2 helps recruit cohesin to transcription start sites and affects the size of chromatin compartments, highlighting an important relationship between histone modification and genome architecture in eukaryotic cells.
Can triad forestry reconcile Europe's biodiversity and forestry strategies? A critical evaluation of forest zoning.
Ambio
December 2024
National Biodiversity Future Centre, Piazza Marina, 61, 90133, Palermo, Italy.
Balancing increasing demand for wood products while also maintaining forest biodiversity is a paramount challenge. Europe's Biodiversity and Forest Strategies for 2030 attempt to address this challenge. Together, they call for strict protection of 10% of land area, including all primary and old growth forests, increasing use of ecological forestry, and less reliance on monocultural plantations.
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