Weakness of wrist muscles has a significant impact on upper limb function in people with tetraplegia. A simple device has been designed to enable clinicians to measure dynamic strength in the very weak muscles of people with tetraplegia. The objective of this study was to test the interrater reliability of the device. Twenty wrists of 12 people with tetraplegia and associated wrist extensor weakness (grade 2-4) were included in the study. The strength of the wrist extensor muscles was measured by blinded assessors on two separate occasions 1-3 days apart. Measurements were conducted in a device that ensured the resistive torque was constant as the wrist moved through full range of motion. Intraclass correlation coefficients and percent close agreement scores were used to measure reliability. The intraclass correlation coefficient was 0.88 (95% CI 0.72-0.95). Repeat measurements of wrist extensor torque were within 0.5 Nm 75% of the time and 0.7 Nm 90% of the time. This device is a simple and reliable way of measuring dynamic wrist extensor strength of people with tetraplegia. It is appropriate for use in the clinical setting.
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http://dx.doi.org/10.3109/09593980903049432 | DOI Listing |
Medicine (Baltimore)
January 2025
Department of Neurology (Nerve-Muscle Unit), Reference Center for Neuromuscular Diseases "AOC," ALS Reference Center, University Hospitals of Bordeaux (Pellegrin Hospital), University of Bordeaux, Bordeaux, France.
Rationale: Locked-in syndrome (and its variant, completely locked-in state) generally has a high mortality rate in the acute setting; however, when induced by conditions such as acute inflammatory polyradiculoneuropathy, it may well be curable such that an attempt at cure should be systematically sought by clinicians.
Patient Concerns: A 52-year-old man presented with acute tetraparesia and areflexia, initially diagnosed as Guillain-Barré syndrome. Despite appropriate treatment, his condition deteriorated, evolving into a completely locked-in state.
Neurogenetics
January 2025
Department of Pediatrics, Erciyes University, Faculty of Medicine, Kayseri, Turkey.
The cytoskeleton, composed of microtubules, intermediate filaments and actin filaments is vital for various cellular functions, particularly within the nervous system, where microtubules play a key role in intracellular transport, cell morphology, and synaptic plasticity. Tubulin-specific chaperones, including tubulin folding cofactors (TBCA, TBCB, TBCC, TBCD, TBCE), assist in the proper formation of α/β-tubulin heterodimers, essential for microtubule stability. Pathogenic variants in these chaperone-encoding genes, especially TBCD, have been linked to Progressive Encephalopathy with Brain Atrophy and Thin Corpus Callosum (PEBAT, OMIM #604,649), a severe neurodevelopmental disorder.
View Article and Find Full Text PDFJ Spinal Cord Med
January 2025
Montecatone Rehabilitation Institute, Imola, Bologna, Italy.
Design: Retrospective observational study.
Objective: To analyze changes in mood states during the acute phase of inpatient rehabilitation for spinal cord injury (SCI) and the factors associated with worse mood states and less improvement.
Setting: Spinal unit in Italy.
World J Orthop
January 2025
Department of Orthopedics, The 940 Hospital of Joint Logistic Support Force of Chinese People's Liberation Army, Lanzhou 730000, Gansu Province, China.
Background: Tuberculosis is among the most devastating infectious diseases worldwide. Spinal tuberculosis is not easy to detect at an early stage, which without effective treatment often leads to spinal deformity and spinal cord damage which in turn cause complications such as paraplegia and quadriplegia. In this study, we established a model using three concentrations of bacteria and carried out a comprehensive evaluation of the model by imaging, general observations, and histopathological and bacteriological studies.
View Article and Find Full Text PDFNat Med
January 2025
Department of Neurosurgery, Stanford University, Stanford, CA, USA.
People with paralysis express unmet needs for peer support, leisure activities and sporting activities. Many within the general population rely on social media and massively multiplayer video games to address these needs. We developed a high-performance, finger-based brain-computer-interface system allowing continuous control of three independent finger groups, of which the thumb can be controlled in two dimensions, yielding a total of four degrees of freedom.
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