The syntheses and cytotoxic activity of coumarin-estrogen conjugates are described. In vitro results indicated that conjugates 10, 11 and 13 show growth inhibitory activities at 5-dose concentration (100, 10, 1, 0.1, 0.01 muM) against the following NCI-7- human breast cancer cell lines: BT-549, HS 578T, MCF 7, MDA-MB-231/ATCC, MDA-MB-435, NCI/ADR-RES, and thus serve as new leads for further development of antibreast cancer agent.
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| http://dx.doi.org/10.2174/157018009787582624 | DOI Listing |
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Synthesis and antiproliferative activity of coumarin-estrogen conjugates against breast cancer cell lines.
Lett Drug Des Discov
March 2009
Florida A and M University, College of Arts and Sciences, Department of Chemistry, 219 Jones Halls, Tallahassee, FL 32307, USA; Tel: (1)-850-599-3509.
The syntheses and cytotoxic activity of coumarin-estrogen conjugates are described. In vitro results indicated that conjugates 10, 11 and 13 show growth inhibitory activities at 5-dose concentration (100, 10, 1, 0.1, 0.
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Florida A&M University, College of Arts and Sciences, Department of Chemistry, Tallahassee, FL 32307, USA.
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