Oleoylethanolamide (OEA) is a biologically active lipid amide that is released by small-intestinal enterocytes during the absorption of dietary fat and inhibits feeding by engaging the nuclear receptor, peroxisome proliferator-activated receptor-alpha (PPAR-alpha). Previous studies have shown that the anorexic effects of systemically administered OEA require the activation of sensory afferents of the vagus nerve. The central circuits involved in mediating OEA-induced hypophagia remain unknown. In the present study, we report the results of in situ hybridization and immunohistochemistry experiments in rats and mice, which show that systemic injections of OEA (5-10 mg kg(-1), intraperitoneal) enhance expression of the neuropeptide oxytocin in magnocellular neurons of the paraventricular nucleus (PVN) and supraoptic nucleus (SON) of the hypothalamus. No such effect is observed with other hypothalamic neuropeptides, including vasopressin, thyrotropin-releasing hormone and pro-opiomelanocortin. The increase in oxytocin expression elicited by OEA was absent in mutant PPAR-alpha-null mice. Pharmacological blockade of oxytocin receptors in the brain by intracerebroventricular infusion of the selective oxytocin antagonist, L-368,899, prevented the anorexic effects of OEA. The results suggest that OEA suppresses feeding by activating central oxytocin transmission.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2900249 | PMC |
| http://dx.doi.org/10.1523/JNEUROSCI.0036-10.2010 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Stress is central to many neuropsychiatric conditions, including alcohol use disorder (AUD). Stress influences the initiation and continued use of alcohol, the progression to AUD, and relapse. Identifying the neurocircuits activated during stress, and individual variability in these responses is critical for developing new treatment targets for AUD, particularly to mitigate stress-induced relapse.
View Article and Find Full Text PDFLGR4 is a key regulator of hepatic gluconeogenesis.
Free Radic Biol Med
January 2025
Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai Key Laboratory for Endocrine Tumor, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Electronic address:
Aims/hypothesis: Emerging evidence underscored the significance of leucine-rich repeat-containing G protein-coupled receptor (LGR) 4 in endocrine and metabolic disorders. Despite this, its role in LGR4 in hepatic glucose metabolism remains poorly understood. In this study we set out to test whether LGR4 regulates glucose production in liver through a specific signaling pathway.
View Article and Find Full Text PDFHemiparasitic plants facilitate ecological restoration of encroached European grasslands.
J Environ Manage
January 2025
Department of Botany and Zoology, Faculty of Science, Masaryk University, Kotlářská 2, CZ-611 37, Brno, Czech Republic.
Species-rich grasslands of temperate Europe are threatened by the spread and increasing dominance of the rhizomatous grass Calamagrostis epigejos. Native hemiparasitic Rhinanthus species have been proposed as biocontrol to suppress C. epigejos, but experimental evidence is limited.
View Article and Find Full Text PDFThe risk of believing that emotions are bad and uncontrollable: association with orthorexia nervosa.
Eat Weight Disord
January 2025
Faculty of Science and Technology, Department of Psychology, Bournemouth University, Poole, UK.
Purpose: This study aimed to explore emotional functioning in individuals with varying levels of orthorexia nervosa (ON) symptoms. Given the established links between emotion dysregulation and other eating disorders (EDs), and the conceptualization of ON within the ED spectrum, this research sought to examine the relationships between ON symptomatology and emotion regulation strategies, alexithymia, and beliefs about emotions.
Methods: A large sample (N = 562) completed self-report measures with high psychometric properties, assessing ON traits (E-DOS), emotion regulation strategies (DERS-SF and ERQ), alexithymia (TAS-20), and beliefs about emotions (ERQ).
Marine microbes suppressed Vibrio and enhanced biological performance of euryhaline rotifer, Brachionus plicatilis.
Mar Pollut Bull
January 2025
Key Laboratory of Aquaculture Nutrition and Feeds (Ministry of Agriculture and Rural Affairs), Key Laboratory of Mariculture (Ministry of Education), Ocean University of China, Qingdao 266100, China. Electronic address:
The excessive use of antibiotics in mariculture has surpassed permitted levels, leading to their release into surrounding waters and accumulation in cultured organisms, which poses risks to human health and highlighting the urgent need for alternatives to reduce antibiotic use. Therefore, the present study aimed to test four microbes including Debaryomyces hansenii, Ruegeria mobilis, Lactobacillus plantarum and Bacillus subtilis, on lowering Vibrio, promoting population increase and survival of Brachionus plicatilis. The digestive enzymes activity including α-amylase, lipase and protease, microbial retention and biochemical composition of rotifers were analyzed.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!