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Optimised stress - intensification of pyocyanin production with zinc oxide nanoparticles.
Microb Cell Fact
July 2024
Department of Chemical and Process Engineering, Faculty of Chemical Technology and Engineering, West Pomeranian University of Technology in Szczecin, Piastów Avenue 42, Szczecin, 71-065, Poland.
Article Synopsis
- Pyocyanin, a valuable blue pigment made by Pseudomonas aeruginosa, has become more sought after due to its unique chemical properties, but it is also expensive to produce.
- Research indicates that using statistical experimentation and low levels of stressors like zinc oxide nanoparticles can significantly boost pyocyanin output.
- Results show that optimal conditions (32℃ and 6.06 µg/mL of nanoparticles) enhance pyocyanin production while higher concentrations hinder it, and these changes involve physiological alterations in the bacteria.
The Host-Pathogen Interplay: A Tale of Two Stories within the Cornea and Posterior Segment.
Microorganisms
August 2023
Department of Ophthalmology and Visual Sciences, Truhlsen Eye Center, University of Nebraska Medical Center, Omaha, NE 68105, USA.
Ocular infectious diseases are an important cause of potentially preventable vision loss and blindness. In the following manuscript, we will review ocular immunology and the pathogenesis of herpesviruses and Pseudomonas aeruginosa infections of the cornea and posterior segment. We will highlight areas of future research and what is currently known to promote bench-to-bedside discoveries to improve clinical outcomes of these debilitating ocular diseases.
View Article and Find Full Text PDFBacteriophage-antibiotic combination therapy against extensively drug-resistant Pseudomonas aeruginosa infection to allow liver transplantation in a toddler.
Nat Commun
September 2022
Laboratory for Molecular and Cellular Technology, Queen Astrid Military Hospital, Brussels, Belgium.
Post-operative bacterial infections are a leading cause of mortality and morbidity after ongoing liver transplantation. Bacteria causing these infections in the hospital setting can exhibit high degrees of resistance to multiple types of antibiotics, which leads to major therapeutic hurdles. Alternate ways of treating these antibiotic-resistant infections are thus urgently needed.
View Article and Find Full Text PDFDeveloping ciprofloxacin dry powder for inhalation: A story of challenges and rational design in the treatment of cystic fibrosis lung infection.
Int J Pharm
February 2022
Pharmaceutical and Molecular Biotechnology Research Centre (PMBRC), Waterford Institute of Technology, Waterford, Ireland.
Cystic fibrosis (CF) is an inherited multisystem disease affecting the lung which leads to a progressive decline in lung function as a result of malfunctioning mucociliary clearance and subsequent chronic bacterial infections. Pseudomonas aeruginosa is the predominant cause of lung infection in CF patients and is associated with significant morbidity and mortality. Thus, antibiotic therapy remains the cornerstone of the treatment of CF.
View Article and Find Full Text PDFGuiding stars to the field of dreams: Metabolically engineered pathways and microbial platforms for a sustainable lignin-based industry.
Metab Eng
May 2022
Institute of Systems Biotechnology, Saarland University, Saarbrücken, Germany. Electronic address:
Lignin is an important structural component of terrestrial plants and is readily generated during biomass fractionation in lignocellulose processing facilities. Due to lacking alternatives the majority of technical lignins is industrially simply burned into heat and energy. However, considering its vast abundance and a chemically interesting richness in aromatics, lignin is presently regarded both as the most under-utilized and promising feedstock for value-added applications.
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