Peculiarities of oxygen supply of a skeletal muscle under normal alimentary conditions and under conditions of alimentary starvation have been studied on spontaneously hypertensive rats (SHR) and normotensive rats (NTR). Calculations of oxygen permeability through hematoparenchymatous barrier (HPB) have shown that it is higher (by 26%) in SHR than in NTR. This difference can be a result of higher content of arachidonic acid and intensity of lipid peroxidation in phospholipids of plasma membranes. After 5-day starvation tension of O2 in skeletal muscle of SHR increased due to a decrease of oxygen demand and increase of oxygen permeability through HPR. The observed modification of fatty-acid spectrum of plasma membrane phospholipids and a sharp decrease of cholesterol content in them can be responsible for an increase of oxygen permeability through HPB.
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