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Antihyperglycemic and antioxidant potential of a lectin from in streptozotocin-induced diabetic rats.
Nat Prod Res
January 2025
Laboratório Integrado de Biomoléculas - LIBS, Departamento de Patologia e Medicina Legal, Universidade Federal do Ceará, Fortaleza, Ceará, Brazil.
This study aimed to evaluate the antihyperglycemic and antioxidant activities of the lectin isolated from (BTL). Diabetes was induced in Wistar rats through low-dose streptozotocin injections. Following the confirmation of hyperglycaemia, the animals were treated with 150 mM NaCl, glibenclamide, or BTL at 600 or 900 mg/kg.
View Article and Find Full Text PDFTrends in childhood cancer: Incidence and survival analysis over 45 years of SEER data.
PLoS One
January 2025
Departments of Global Pediatric Medicine and Oncology, St. Jude Children's Research Hospital, Memphis, TN, United States of America.
Background: The SEER Registry contains U.S. cancer statistics.
View Article and Find Full Text PDFPutative biomarkers of hepatic dysfunction in critically ill sepsis patients.
Clin Exp Med
January 2025
Pediatrics, Western University, London, ON, Canada.
Sepsis is a major cause of morbidity and mortality worldwide. Among the various types of end-organ damage associated with sepsis, hepatic injury is linked to significantly higher mortality rates compared to dysfunction in other organ systems. This study aimed to investigate potential biomarkers of hepatic injury in sepsis patients through a multi-center, case-control approach.
View Article and Find Full Text PDFHomozygous Familial Hypercholesterolemia Treatment: New Developments.
Curr Atheroscler Rep
January 2025
Carbohydrate and Lipid Metabolism Research Unit, Department of Medicine, University of the Witwatersrand, Johannesburg, South Africa.
Purpose Of Review: Homozygous familial hypercholesterolaemia (HoFH) is characterized by marked elevation of low-density lipoprotein cholesterol (LDLC) and premature atherosclerotic cardiovascular disease. This is a review of novel pharmacological therapies to lower LDLC in patients with HoFH.
Recent Findings: Novel therapies can be broadly divided by whether their efficacy is dependent or independent of residual low-density lipoprotein receptor (LDLR) function.
Basic Science and Pathogenesis.
Alzheimers Dement
December 2024
HuaShan Hospital, Fudan University, Shanghai, China, Shanghai, China.
Background: To investigate the physiological clearance of circulating Aβ by the liver and its role in the pathogenesis of Alzheimer's disease (AD).
Method: Immunostaining, near-infrared imaging, and flow cytometry were used to explore the physiological clearance of Aβ by the liver and the impact of aging on Aβ clearance. Liver-specific LRP-1 knockdown and functional LRP-1 minigene (mLRP-1) expression in mice with AD were used to explore the effects of hepatic Aβ clearance on AD pathogenesis and treatment.
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