AI Article Synopsis
- - Resveratrol, a natural compound found in grapes and red wine, has shown potential neuroprotective benefits, especially regarding cognitive function during aging.
- - In a study with mice, those receiving long-term resveratrol supplementation performed better on spatial memory tasks and exhibited healthier blood vessels in the brain compared to non-treated mice.
- - The research suggests that resveratrol may help preserve cognitive abilities in aging by promoting cerebrovascular health, although it didn’t affect the number of cholinergic cells or their fiber density.
Article Abstract
Resveratrol, a natural polyphenol abundant in grapes and red wine, has been reported to exert numerous beneficial health effects. Among others, acute neuroprotective effects of resveratrol have been described in several models of neurodegeneration, both in vitro and in vivo. In the present study we examined the neuroprotective effects of long-term dietary supplementation with resveratrol in mice on behavioral, neurochemical and cerebrovascular level. We report a preserved cognitive function in resveratrol-treated aging mice, as shown by an enhanced acquisition of a spatial Y-maze task. This was paralleled by a higher microvascular density and a lower number of microvascular abnormalities in comparison to aging non-treated control animals. We found no effects of resveratrol supplementation on cholinergic cell number or fiber density. The present findings support the hypothesis that resveratrol exerts beneficial effects on the brain by maintaining cerebrovascular health. Via this mechanism resveratrol can contribute to the preservation of cognitive function during aging.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2874408 | PMC |
| http://dx.doi.org/10.3389/neuro.24.004.2009 | DOI Listing |
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