AI Article Synopsis
- A rat model of jugular venous reflux (JVR) is important for studying various cerebral conditions, but needs better validation methods for effectiveness.
- Researchers used neck 3D time-of-flight magnetic resonance angiography (MRA) to assess JVR before and after surgery, noting enhanced venous structures post-operation.
- The study concluded that this MRA technique is a valuable noninvasive tool for tracking cerebral blood flow and changes in vascular structures over time in research settings.
Article Abstract
Background And Purpose: A rat model of jugular venous reflux (JVR) is widely used in studies of cerebral arteriovenous fistula, cerebral venous hypertension and chronic cerebral hypoperfusion. However, methods to validate the effectiveness of the operation are needed.
Methods: We performed neck 3-dimensional time-of-flight magnetic resonance angiography (MRA) with a clinical scanner in a rat model of JVR before and after the operation. High-resolution arterial angiography of the rat neck was acquired with maximum intensity projection.
Results: In the JVR model, the success of the operation was validated by enhanced venous structures on MRA. The angiogram also provided information on the height of JVR and the status of other neck vessels.
Conclusions: In conclusion, neck 3-dimensional time-of-flight MRA is a useful noninvasive method for monitoring the blood flow in multiple cerebral vessels in this animal model. It also revealed the height of JVR, collateral development and changes in vessels over time in longitudinal studies. This information should be considered in the evaluation of the animal model.
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| http://dx.doi.org/10.1159/000316060 | DOI Listing |
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