Background: The effect of uncontrolled chronic glycemia (UCG) in the diabetic patient with a neoplasm (DPN) has not been evaluated during the early postoperative period. Our objective was to determine the frequency of early surgical complications in the DPN with UCG.
Methods: A cohort of 184 consecutive diabetic patients who had a histological malignant diagnosis were studied; they were matched with 184 non-diabetic controls by age, gender, neoplasm type and surgery, those who received chemotherapy or irradiation 30 days before surgery were excluded. Fasting blood glucose, HbA1c, presence of diabetic complications and co-morbidity before surgery; type of surgery and postoperative early morbidity and mortality were measured.
Results: The DPN with UCG had a higher frequency of surgical postoperative complications than their controls. The presence of comorbidity (p < 0.011) and HbA1c > 6.5 % (p < 0.011) were independent and ominous significant predictors.
Conclusions: Preoperative UCG increases the risk of early surgical complications in DPN.
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Intern Emerg Med
January 2025
Emergency Department, Limoges University Hospital, Limoges, France.
Implementation of a regional sepsis program to improve compliance with sepsis care bundles and optimize septic patient management and outcomes in the Emergency Department (ED). The program included a multifaceted intervention in 8 EDs: creation of a regional sepsis team, meetings, education (yearly 6-h course and site visits) and sepsis alert. Clinical practice was evaluated in each ED during 1 month every year over 3 years.
View Article and Find Full Text PDFLangenbecks Arch Surg
January 2025
Unidad de Cirugía Endocrina, Hospital Universitari de Bellvitge, C/ Feixa Llarga s/n, L'Hospitalet de Llobregat, Barcelona, E-0897, Spain.
Purpose: Measurement of intraoperative intact parathyroid hormone (ioPTH) levels is a reliable predictor of postsurgical hypocalcemia. We assessed the optimal cutoff values of ioPTH decline for predicting postoperative early and permanent hypoparathyroidism.
Methods: This was a retrospective study of a prospectively maintained database of patients undergoing thyroid surgery in a tertiary care hospital in L'Hospitalet de Llobregat (Barcelona, Spain).
Dent Med Probl
January 2025
Department of Hygiene, Epidemiology and Ergonomics, Medical University of Bialystok, Poland.
Background: Titanium (Ti) biomaterials are widely used in the surgical management of maxillofacial trauma, in oncology and orthognathic surgery. Although Ti is considered highly biocompatible, adverse reactions at the implant site have been reported in numerous clinical studies. However, the influence of Ti mandibular implants on glutathione metabolism, nitrosative stress and systemic inflammation has not been investigated to date.
View Article and Find Full Text PDFPediatr Blood Cancer
January 2025
Department of Oncology, Children's Hospital of Nanjing Medical University, Jiangsu, China.
Background: Compared to colorectal cancer (CRC) in adults, CRC in children is extremely rare. Although its incidence has increased recently, there is a lack of clinical research on the disease. Inherited cancer susceptibility syndromes (ICSS), a group of disorders in which patients are predisposed to susceptibility to a wide range of tumors as a result of pathogenic mutations in genes in their germ line, are an important cause of CRC in children.
View Article and Find Full Text PDFClin Transplant
February 2025
Division of Pediatric Cardiology, Mount Sinai Kravis Children's Hospital, New York, New York, USA.
Introduction: The present study aimed to assess the clinical outcomes of pediatric heart transplant patients whose donor hearts were preserved with the SherpaPakCardiac Transport System.
Methods: All pediatric patients undergoing heart transplantation at our center between January 2020 and June 2024 were included and described. Vasoactive inotropic score (VIS) was calculated.
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