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Fungal highly reducing polyketide synthases (hrPKSs) are remarkable multidomain enzymes that catalyse the biosynthesis of a diverse range of structurally complex compounds. During biosynthesis, the ketosynthase (KS) and acyltransferase (AT) domains of the condensing region are visited by the acyl carrier protein (ACP) domain during every cycle, catalysing chain priming and elongation reactions. Despite their significance, our comprehension of how these steps contribute to biosynthetic fidelity remains poorly understood.
View Article and Find Full Text PDFEffect of Superficial Large Vessel Insulation Combined with Self-heating Warm Paste on Intraoperative Hypothermia in Patients Undergoing Urologic Surgery.
Arch Esp Urol
December 2024
Surgical Complex, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, 317000 Taizhou, Zhejiang, China.
Objective: This study aimed to explore the application effect of superficial large vessel insulation combined with self-heating warm paste on intraoperative hypothermia in patients undergoing urologic surgery.
Methods: This study included 313 patients who underwent urologic surgery in Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University from May 2023 to March 2024. After 13 patients with incomplete clinical data, abnormal basal metabolism and preoperative skin injury were excluded, 300 patients were finally included.
Taking a stand, ready or not: navigating sensitive end-of-life care conversations in patients with end-stage heart failure.
Eur J Cardiovasc Nurs
January 2025
Department of Oncology and Palliative Care, North Zealand Hospital, Dyrehavevej 29, 3400 Hillerød, Denmark.
Aims: Patients with heart failure (HF) often experience delayed identification of palliative care needs. While communication with HF patients and their caregivers is increasingly stressed, systematic conversations about end-of-life care wishes remain a gap. This study explores a dyad experience of Advance Care Planning (ACP) conversations in an HF outpatient clinic.
View Article and Find Full Text PDFIn subclinical AF, apixaban vs. aspirin reduced stroke or systemic embolism at 3.5 y, regardless of duration of recent subclinical AF episodes.
Ann Intern Med
January 2025
University of Michigan, Ann Arbor, Michigan, USA (E.R.B.).
GIM/FP/GP: [Formula: see text] Cardiology: [Formula: see text].
View Article and Find Full Text PDFIn T1D, weekly efsitora was noninferior to daily degludec for reducing HbA but increased severe hypoglycemia at 26 wk.
Ann Intern Med
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Mayo Clinic, Rochester, Minnesota, USA (F.L., M.R.G., V.M.M.).
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