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Stiffness-induced modulation of ERG transcription factor in chronic liver disease.
NPJ Gut Liver
October 2024
Department of Visceral Surgery and Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Chronic liver disease (CLD) is characterised by liver sinusoidal endothelial cells (LSECs) dysfunction. Mechanical forces and inflammation are among the leading factors. ETS-related gene (ERG) is an endothelial-specific transcription factor, involved in maintaining cell quiescence and homeostasis.
View Article and Find Full Text PDFPlasma exchange-sensitive syncytial glomerulopathy in a kidney transplant patient.
Virchows Arch
August 2024
Unità Operativa di Nefrologia, Azienda Ospedaliero-Universitaria Parma and Dipartimento Di Medicina E Chirurgia, Università Di Parma, Via Gramsci 14, 43100, Parma, Italy.
Microvascular inflammation (MVI), defined as the presence of glomerulitis and/or peritubular capillaritis, is the key histological lesion of anti-HLA donor-specific antibodies (DSA)-related antibody mediated rejection, but recently other possible mechanisms of MVI have emerged. However, except for peritubular capillary C4d deposition that is more frequently observed in the presence of anti-HLA-DSA, histological features are similar regardless of MVI origin. Therefore, accurately describing patterns of MVI may help differentiate etiologies and drive therapeutic choices.
View Article and Find Full Text PDFExosomal delivery of miR-200b-3p suppresses the growth of hepatocellular carcinoma cells by targeting ERG- and VEGF-mediated angiogenesis.
Gene
December 2024
Department of Pathology and Experimental Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2-5-1 Shikata, Kita-ku, Okayama 700-8558, Japan. Electronic address:
Hepatocellular carcinoma (HCC) remains a lethal malignancy with limited treatment options. Recent discoveries have highlighted the pivotal role of miRNAs in HCC progression. We previously reported that the expression of miR-200b-3p was decreased in HCC cells and exosomal miR-200b-3p from hepatocytes inhibited angiogenesis by suppressing the expression of the endothelial transcription factor ERG (erythroblast transformation-specific (ETS)-related gene), leading to the hypothesis that the delivery of this miRNA may inhibit angiogenesis and suppress HCC growth in vivo.
View Article and Find Full Text PDFGerm line ERG haploinsufficiency defines a new syndrome with cytopenia and hematological malignancy predisposition.
Blood
October 2024
Centre for Cancer Biology, SA Pathology and University of South Australia, Adelaide, SA, Australia.
Article Synopsis
- The genomics era has led to the identification of the ERG gene as a new autosomal dominant predisposition factor for bone marrow failure (BMF) and hematological malignancies (HM), crucial for blood cell development and function.
- Research found several rare ERG variants associated with thrombocytopenia and various forms of HM, showing onset typically before age 40.
- Functional studies indicated that many ERG variants disrupt its role as a transcription factor, leading to ineffective blood cell production, with implications for clinical diagnosis and treatment strategies for affected patients and families.
Erythroblast transformation-specific-related gene promotes metastasis of oral squamous cell carcinoma by transcriptionally upregulating peroxiredoxin 1.
J Oral Pathol Med
July 2024
Department of Stomatology, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu, China.
Article Synopsis
- The study investigates the role of the transcription factor ERG in oral squamous cell carcinoma (OSCC) and how it affects the growth and behavior of cancer cells.
- Researchers collected tissue samples from 54 patients and used various assays to analyze gene expression and cell characteristics.
- Findings suggest that high levels of ERG promote tumor growth by increasing PRDX1 expression, which, in turn, enhances cell proliferation and invasion while reducing apoptosis in OSCC.
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