AI Article Synopsis
- Tumor necrosis factor (TNF) impacts endothelial cells, causing changes that lead to organ damage.
- In the lungs, this results in interstitial and alveolar edema.
- In the liver and kidneys, TNF causes various issues like Kupffer cell activation, changes in blood vessel permeability, and damage to kidney structures.
Article Abstract
Tumor necrosis factor exerts the systemic influence on endothelial cells in vivo. Structural changes in endotheliocytes lead to specific damage in the organs. Interstitial and alveolar edema develops in lung. Kupffer cell activation, change of sinusoid endothelial cell porosity, lipid dystrophia of hepatocytes are revealed in liver, damage of glomerular and peritubular capillaries, dystrophic changes of tubular epithelial cells are found out in kidney. The data obtained indicate that endothelial cells in microvessels are one of major cellular targets for action of tumor necrosis factor.
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