Hepatocellular carcinoma (HCC) is one of the most common malignant tumors in China, which is mainly caused by hepatitis B virus (HBV) infection. The X gene product (HBx) of HBV has extensive trans-activating functions. HBx affects the signal transduction, apoptotic cell death and cell cycle through interaction with variety intracellular proteins in infected hepatocytes. In view of the importance of HBx in HBV replication and in hepatic cell functions, the role of HBx in HCC development has been attracting great attention.
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| http://dx.doi.org/10.3785/j.issn.1008-9292.2010.03.020 | DOI Listing |
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