A decrease in the level of epileptic susceptibility to a strong sound which induces the epileptiform seizures has been studied in KM-strain of rats. Reflectory control of seizure activity, i.e. a decrease in their frequency rate has been shown during a prolonged action of the epileptogenic stimulus. The conditions and dynamics of the decreased epileptic susceptibility during systematic presentation of the epileptogenic stimulus have been found to correlate with eight habituation criteria. This effect is identified as habituation to a pathologic action, and its typical features are described. The results characterizing phenomenological similarity of the processes found in experiments and in clinical studies are discussed. The observed blocking of seizures induced by habituation to the sound is treated as shaping of some defensive antiepileptic processes.
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