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Child-Pugh Score and Vitamin D: Exploring a New Frontier in Liver Cirrhosis Assessment.
Cureus
November 2024
Medicine, Shri. B. M. Patil Medical College Hospital and Research Centre, Vijayapura, IND.
This study investigates the relationship between vitamin D levels and liver cirrhosis severity, a leading cause of global morbidity and mortality. Chronic liver diseases, stemming from conditions such as hepatitis, alcohol use, non-alcoholic fatty liver disease, autoimmune diseases, and cryptogenic disorders, disrupt vitamin D metabolism, as the liver converts dietary and skin-derived vitamin D into 25-hydroxyvitamin D (25[OH]D), the primary circulating form. The cross-sectional study conducted at the Department of General Medicine of BLDE (DU) Shri.
View Article and Find Full Text PDF[Bronchiolitis obliterans organizing pneumonia after radiotherapy: A systematic review and case report].
Cancer Radiother
December 2024
Département de radiothérapie, CHU de Saint-Étienne, Saint-Priest-en-Jarez, France; Département de radiothérapie, centre hospitalier de Roanne, Roanne, France. Electronic address:
Purpose: Bronchiolitis obliterans with pneumonic organization, or organizing pneumonia (OP), is an inflammatory disorder of the lungs, which can be triggered following pulmonary attacks of infectious or non-infectious origin. The non-infectious origins of OP include various entities including connective tissue diseases, exposure to toxic substances, medications, autoimmune diseases, and thoracic radiotherapy. The objective of this article is to summarize the literature on post-radiotherapy organized pneumonia, its etiologies, its clinical and radiological characteristics, as well as its treatment.
View Article and Find Full Text PDFSerum Ferritin Levels and Liver-Related Events in Individuals With Steatotic Liver Disease: A Longitudinal Cohort Study.
Aliment Pharmacol Ther
November 2024
Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.
Background: Serum ferritin has been suggested as a potential biomarker associated with disease progression in metabolic dysfunction-associated steatotic liver disease (MASLD).
Aims: We investigated the association between serum ferritin levels and liver-related events (LREs) in individuals with steatotic liver disease (SLD).
Methods: This cohort study included 17,560 adults with SLD (MASLD [n = 15,744], MASLD with increased alcohol intake (MetALD) [n = 1103] and cryptogenic SLD [n = 713]) without LRE at baseline.
Impact of PNPLA3 in Lean Individuals and in Cryptogenic Steatotic Liver Disease.
Liver Int
November 2024
Department of Gastroenterology and Hepatology, Saiseikai Suita Hospital, Suita, Japan.
Article Synopsis
- - MASLD, previously known as NAFLD, can affect people with normal body weight, splitting into two categories: lean MASLD (with cardiometabolic risk factors) and cryptogenic steatotic liver disease (without these factors).
- - Research shows that the PNPLA3 rs738409 genetic variant is more prevalent in individuals with lean NAFLD compared to those who are overweight or obese, but cardiometabolic risk factors usually still play a role in liver issues.
- - Although the PNPLA3 gene is linked to severe liver conditions and complications, its specific effects on lean individuals with NAFLD have not been thoroughly investigated.
Metabolic dysfunction-associated steatotic liver disease, liver fibrosis and risk of cardiovascular disease: A prospective cohort study.
Nutr Metab Cardiovasc Dis
December 2024
Department of Epidemiology and Health Promotion, Institute for Health Promotion, Graduate School of Public Health, Yonsei University, Seoul, Republic of Korea.
Background And Aims: In patients with NAFLD, liver fibrosis increases liver-related complications, but there is controversy about the increase in CVD. Based on a prospective cohort study, this study investigated the risk of cardiovascular disease due to liver fibrosis in patients with metabolic dysfunction-associated steatotic liver disease (MASLD).
Methods And Results: This study analyzed KCPS-II prospective cohort that tracked 104,399 people who participated in health check-ups at 18 institutions nationwide from 2004 to 2013.
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