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Impact of cerium doping on the peroxidase-like activity of metal-organic frameworks.
Dalton Trans
January 2025
Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province and State Key Laboratory of Applied Organic Chemistry, Frontiers Science Center for Rare Isotopes, College of Chemistry and Chemical Engineering, Lanzhou University, 73000 Lanzhou, China.
Hydrogen peroxide, phenols, amines, aldehydes, and other substances can easily damage intracellular biomacromolecules. Although natural peroxidases can convert these harmful substances into benign ones, the high costs, poor stabilities, and stringent application conditions associated with these enzymes necessitate the exploration of artificial mimics. In this study, Ce-doped MIL-101(Fe)-NH and MIL-101(Fe)-NO were synthesized with varying compositions a solvothermal method.
View Article and Find Full Text PDFAssociations of aldehyde exposure with serum uric acid and hyperuricemia among U.S. adults from NHANES 2013-2014.
Heliyon
December 2024
Key Laboratory of Cardiovascular Epidemiology & Department of Epidemiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100037, China.
Background: Aldehyde is a kind of important environmental pollutant, which has been demonstrated to be associated with increased risks of various chronic diseases with the economic and social development. However, the effects of aldehydes on serum uric acid (SUA) and hyperuricemia remained inexplicit, and the potential mediating pathways for this relationship needed to be addressed.
Methods: This study investigated the associations of individual and mixed aldehydes with SUA and hyperuricemia among 1588 U S.
Clinical presentation and management challenges of sphingosine-1-phosphate lyase insufficiency syndrome associated with an SGPL1 variant: a case report.
BMC Pediatr
January 2025
Geriatric Mental Health Research Center, Department of Psychiatry, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Background: This case report describes a unique presentation of sphingosine-1-phosphate lyase insufficiency syndrome (SPLIS) caused by a rare SGPL1 variant, highlighting the diagnostic and management challenges associated with this condition.
Case Presentation: A 2-year-old Iranian female presented with steroid-resistant nephrotic syndrome (NS), primary adrenal insufficiency (AI), growth delay, seizures, and hyperpigmentation. Laboratory evaluation revealed hypoalbuminemia, significant proteinuria, hyperkalemia, and elevated adrenocorticotropic hormone (ACTH) levels.
Mass-spectrometry-based quantitative proteomic analysis reveals that methylglyoxal and carnosine influence oxidative stress and RNA-processing associated proteins in renal proximal tubule epithelial cells.
Mol Biol Rep
January 2025
Department of Endocrinology, the First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, 230022, People's Republic of China.
Background: Tubular injury triggered by hyperglycemia is an important pathological characteristic in diabetic nephropathy (DN). Accumulated advanced glycation end products and their precursor methylglyoxal (MGO), contribute to the development of DN. Carnosine has been shown to prevent the development of DN but the underlying mechanism still needs to be studied in depth.
View Article and Find Full Text PDFSerum levels of oxidative stress, IL-8, and pepsinogen I/II ratio in Helicobacter pylori and gastric cancer patients: potential diagnostic biomarkers.
BMC Gastroenterol
January 2025
Department of Biochemistry, Faculty of Medicine, Iran University of Medical Sciences, P.O. Box: 1449614525, Tehran, Iran.
Background And Aim: Helicobacter pylori (H.pylori), a gram-negative bacterial pathogen associated with an increased risk of gastric cancer. This study investigates potential factors in the incidence of gastric cancer in patients with H.
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